Lecture 13: COPD

Question 1

COPD: Pharmacology

Answer 1

• Bronchodilators
• Inhaled corticosteroids
• Long term oxygen therapy
• PDE4 inhibitors
• Theophylline (rarely)

Question 2

Asthma: airway inflammation

Answer 2

Acute

• Airway constriction
• Airway edema vasodilation
• Mucus hypersecretion

Chronic “remodeling”

• Subepithelial fibrosis
• Smooth muscle
• hyperplasia/hypertrophy
• New vessel formation
• Goblet cell hypertrophy