Lecture 13 Chrono Pharmacology

Question 1

Determining Factors of efficacy

Answer 1

Pharmokinetics and pharmodynamics

Question 2

How is absorption affects by clock

Answer 2

Rythms in stomach and intestines
Gastric pH
Gastric blood flow
mobility of gut wall

Question 3

How is metabolism effected`

Answer 3

Liver
Phase 1,2,3 Metabolism
Paracetamol
Hepatobililary System- bile salts
bile recyling
mutlti drug exporter MDR1

Question 4

How is extrection effected

Answer 4

Kidney
Renal Blood flow
urine pH

Question 5

Relevance of asthma

Answer 5

increases amplitude of bronchiol dilation- bigger dilation at night
drugs have a greater % dilations when admistred in the morning

Question 6

what Drug for asthma?

Answer 6

theophylline- bigger peak at when taken at night 2100, where most incidents happen

Question 7

Explain APAP(paracetemol) metabolism?

Answer 7

Phase 1 metabolism- CRP P450 stystem produced NAPK1(detoxified by gluthione)

Question 8

what are the control of APAP toxicity?

Answer 8

Ebox PARAZIP targets D BOX P450 oxidoreductase

P450 OR is seen to be important for detoxification.

Question 9

Chronotypes

Answer 9

Age- clock affected by serum not protein