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Immunology Exam 2 > Lecture 12- Extra NC's > Flashcards

Lecture 12- Extra NC's Flashcards

1
Q

What are the 4 functions of Th1 cells?

A

Kills intracellular pathogens
Promotes tumor immunity/autoimmunity
Classical activation of macrophages
Produces IgG antibodies

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2
Q

What are the 5 functions of Th2 cells?

A 
Kills extracellular pathogens
Increases Allergies
Activates Eosinophils and Mast Cells
Alternative activation of macrophages
Produces IgE antibodies
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3
Q

What are the 2 functions of Th17 cells?

A

Kills extracellular pathogens

Neutrophilic and Monocytic inflammation

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4
Q

What is the function of IL-2?

A

Survival signal, suppresses apoptosis

Stimulates clonal expansion of T cells

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5
Q

What is the function of IL-4?

A

B cell switching to IgE

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6
Q

What is the function of IL-5?

A

Activation of Eosinophils

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7
Q

What is the function of IL-17?

A

Stimulates acute inflammation

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8
Q

What is the function of IL-22?

A

Maintenance of epithelial barrier function

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9
Q

What are the 2 functions of Treg cells?

A

Suppresses tumor immunity

Maintains lymphocyte homeostasis

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10
Q

What cytokines are used to differentiate CD4+ cells into Treg cells?

A

TGF-beta

IL-2

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11
Q

What cytokines are used to differentiate CD4+ cells into Th1 cells?

A

IL-12

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12
Q

What cytokines are used to differentiate CD4+ cells into Th2 cells?

A

IL-4

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13
Q

What cytokines are used to differentiate CD4+ cells into Th17 cells?

A

TGF-beta
IL-6
IL-21

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14
Q

What are the 3 signature cytokines for Treg cells?

A

TGF-beta
IL-10
IL-35

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15
Q

What are the 2 signature cytokines for Th1 cells?

A

IFN-gamma

TNF

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16
Q

What are the 3 signature cytokines for Th2 cells?

A

IL-4
IL-5
IL-13

17
Q

What are the 5 signature cytokines for Th17 cells?

A 
IL-17A
IL-17F
IL-21
IL-22
CCL20
18
Q

What are the transcription factors found within the cell for Treg cells?

A

STAT6

FOXP3

19
Q

What are the transcription factors found within the cell for Th1 cells?

A

STAT4

T-bet

20
Q

What are the transcription factors found within the cell for Th2 cells?

A

STAT6

GATA3

21
Q

What are the transcription factors found within the cell for Th17 cells?

A

STAT3

RORgammat

Immunology Exam 2 (10 decks)

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