lecture 12 Flashcards
cancer proprities

properities of cancer cell

cancer cell loss
contact inhibition and have altered morphology
cancer caused by
accumulation mutation that activated oncogenes and inhibit tumor suppressores

single transduction pathway

scr functions downstream of integrins factor recptor

ras
bladder carcinoma
met oncogene
hepatocarcinoma
hst
stomach carcinoma
erb b
breast cancer
ras GTPNGDP CYCLE

RAS DO

HOW ARE PROTO ONCOGENE CONVERTED TOONCOGENES

C MYC IS OFTEN OVER EXPRESSED DUE TO
CHROMOSOMAL TRANSLOCATION

C MYC IS TRANSCRIPTION FACTOR

CELL cycle progression is controlled by

control of G1 to s phase movement

the restriction point is controlled by phosphorylation of pRb

p53 is tumor supporessor

p53 is actived when

the oncogenic checkpoint

the hallmarks of cnacer

sustaining proliferative signaling

dna turmor viruses target pRB and p53

evading growth suppressor

resisting cell death

caspase targets

two major apoptotic pathways

resisting cell death

the death recptor pathway

the basic Extrinsic apoptotoic pathway

the mitochondrial intrinsic pahtway

apoptosis controlled by the balance of
proapoptotic and prosurvivial factors at the mitochondria

the mitochondrial apoptotic pathway

BCL2

inducing angiogensisi

angiogensisi is controlled by

limitless preplicative potential

telomer lenght vs cell divisons

telmomeres is

telomerase and dna replication

enter telomerase

transcriptional control of metastasis in cancer

altered metabliism

aktoncogene

lifesthle choices decrease cancer
