Lecture 12

Question 1

Can we regenerate a finger tip ?

Answer 1

Until 5 years old, we have the capability of regenerating a finger tip

Question 2

what are the 2 macrophage phenotypes ?

Answer 2

M1 : maintain inflammatory state in order to wait for all the other cells to arrive to the wound site

M2 : release cytokines to promote a regenerative environment -> proliferation and differention of progenitor cells to repair tissue.

Question 3

what are the 2 important roles of immune cells in wound healing ?

Answer 3

1) clean wound and fight infection

2) release cytokines that facilitate the regeneration of new tissue by the proliferation cells

Question 4

What is the worst thing someone could do if they cut their finger tip ?

Answer 4

Close the wound (suture skin together) because that prevent the clotting to happen in a physiological way

Question 5

What are the 3 main approaches to tissue regeneration ?

Answer 5

1) cell therapy : stem cells

2) materials and cytokines : stimulate our already existing cells with signals

3) gene therapy : make our cells produce the signals

Question 6

what are the three stem cells therapies that are accredited to work ?

Answer 6

1) hematopoietic SC (bone marrow transplant)

2) keratinocyte SC (skin grafts)

3) corneal SC (corneal epithelium)

Question 7

What can MSCs be used for ?

Answer 7

1) tissue regeneration (skeletal lineages)

2) they also secrete immune modulating factors -> they can help other cells to regenerate the tissue