Lecture 11.1 Neoplasia Flashcards
What dose a reactive stroma contain?
Endothelial cells and blood vessels.
Describe benign neoplastic cells.
Slow growth, well circumscribed, unable to metastasise.
What are the cytological atypia?
Larger nuclei, varies in size, often hyperchromatic. Contains a coarse nuclear chromatin, and architectural disorganisation.
In squamous cell carcinoma, we can see intracellular bridges and keratin pearls.
What would we see with an adenocarinoma?
Glandular tumour, see lumen.
What does the tumour microenvironment comprise of?
Stroma: Fibroblasts, ECM, endothelial cells, immune cells.
Tissue in which tumour is located.
Remodelling of microenvironment via cytokines and growth factors.
How can we define the pre malignant stage?
When there is dysplasia (atypia) but has not penetrated through basement membrane.
Once they invade BM and submucosa, lose their adhesiveness and attach to stromal components producing antigenic agents, they are termed invasive neoplasms.
