Lecture 11 - evolution in real time Flashcards

1
Q

What is evolution in real time?

A
  • examples of evolution in action
  • applications - disease & epidemiology
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2
Q

How did evolution occur in the distant past?

A

accumulation of lots of small changes at the genetic level that then translates into changes at the phenotypic level

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3
Q

What is evolution?

A
  • evolution is gradual
  • proceeds by the accumulation of small changes
  • big jumps are thought to be unlikely
  • the rate of evolution varies through time
  • macro-evolution is slow
  • micro-evolution is fast
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4
Q

What is a well known example of rapid micro evolution?

A

biston betularia - very fast responses to change (deposition of soot on trees turned them black leading to a change in environment) - selective force, occurred over a few years

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5
Q

What causes rapid evolutionary change?

A
  • competition
  • exploitation
  • climate change
  • parasites
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6
Q

What is competition?

A
  • competition occurs when 2 species have similar requirements
  • e.g. food/shelter
  • 2 species with very similar requirements can’t coexist
  • 1 species must either go extinct or evolve different requirements
  • it is usually thought that ecological process of extinction is faster than evolution
  • hence extinction is thought to be more likely
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7
Q

Describe Darwin’s finches

A

different features for different pressures - classic example of radiation wide species
- competition is shaping the evolution of species

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8
Q

What occurred in response to competition?

A

the evolution of bill size
- different bills for different food sources
- increase in competition led to a reduced bill size (alternative food source - smaller seeds)
- rates of change are close to values predicted from heritability of the trait

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9
Q

What is exploitation?

A

humans do something to natural populations because we want to harvest them for food or another resource
- many species are exploited by humans in some way. Much exploitation is selective - e.g. harvest the biggest. This is exactly like the process of natural selection

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10
Q

How can human impacts lead to rapid evolution?

A
  • hunting of Bighorn sheep
  • hunted as ‘trophies’
  • large rams are a target
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11
Q

Describe the effects of selective hunting on fitness & population size

A
  • reduction in animal size
  • reduction in horn length
  • fluctuations in population size
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12
Q

Describe the evolution of body size & maturity in cod

A
  • cod are fished for food
  • nets target larger fish
  • contain an intermediate life cycle (sexual maturity depends on size)
  • cold environments often lead to slower development and as a result can reach sexual maturity a lot later
  • fishing removes the larger fish from the population. This imposes a natural selection on reproduction. If an individual takes too long to get to maturity, it doesn’t reproduce and therefore isn’t able to pass on their genes (selective pressure on maturation)
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13
Q

Describe changes in maturation schedules

A
  • maturation in 1987 was at a younger age & smaller than 1980
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14
Q

What is a good environment?

A

lots of resources, temperature is good, suitable conditions = large tree growth

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15
Q

What is a poor environment?

A

(e.g. much colder/hotter) = don’t grow as fast, some die, they don’t do as well as they could’ve

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16
Q

What does a poor environment lead to?

A

plant changing time of flowering

17
Q

Describe phenology & climate change

A
  • negative relationship between flowering date & temperature in British plant
  • averaged across 250 years & 405 species
  • flowering later as it gets warmer, as predicted from model
18
Q

What are parasites?

A

parasites are reliant on their host to be able to spread from host to host. As a result there is a lot of selective pressure - as the hosts don’t want to spread the parasite

19
Q

Describe rabbits & myxomatosis

A

myxomatosis - used to try and control their spread

20
Q

Describe co-evolution in real time

A
  • European rabbits were introduced to Australia in 1859
  • Enormous capacity for reproduction
  • Reached pest status
  • Biological control - myxoma virus

Rabbits have rapid enthusiastic reproduction. Few natural predators. Created a huge population.

  • became a pest
  • virus (myxoma) introduced to reduce rabbit population
21
Q

What is coevolution of virulence & resistance?

A

1st epidemic - 99% mortality
2nd epidemic - 90% mortality
3rd epidemic - 40-60% mortality

22
Q

What are selection pressures on parasites?

A
  • death of hosts stops spread of parasite
  • high virulence of parasite leads to short period of spread
  • lower virulence leads to more secondary cases
  • hence selection on parasites for less virulence
  • higher exposure –> resistance
23
Q

What is the link between parasites & evolution?

A
  • parasites provide some of the best evidence for evolution in action
  • parasites have a large number of generations in short time
  • intense ell ruin pressures on host
  • hence rapid evolution

This has important biomedical applications

24
Q

What is phylodynamic data?

A
  • virus gene sequences sampled at different points in time
  • immunological, epidemiological or medical data is often also available
  • phylogenetic history estimated on real time-scale (e.g. years)

Measles & influenza have different phylogeny

25
Q

What can phylogeny tell us?

A
  • phylogeny tells us about the evolutionary history of a group
  • it tells us which lineages have gone extinct & when they did
  • as well as which ones have survived
  • can map on other data & look at phylodynamics
26
Q

What is the selection of measles?

A

no selection on measles virus - spread randomly

27
Q

What is the selection of influenza?

A

the shape of this phylogeny reveals imprint of selection

28
Q

What are other applications of fast evolution?

A
  • evolution of pesticide resistance
  • cancer treatment & drug resistance
  • superbugs