Lecture 10: Snares 1

Question 1

Learning Objectives

Answer 1

● Experiments to show SNARE role in membrane fusion
●List physiological systems which require membrane fusion
● Discuss experimental evidence for role of SNARE in membrane fusion
● Describe key features of SNARE molecules
● Discuss WHY SNAREs are required for membrane fusion

Question 2

List physiological systems which require membrane fusion (chatgpt)

Answer 2

● Neurotransmission
● Endocytosis
● Exocytosis
● Autophagy (cellular recycling)
● Viral infection
● Fertilization

Question 3

What can VAMP be cleaved by?

Answer 3

●Botulinum B
● Tetanus toxin

Question 4

What process provides energy for membrane fusion?

Answer 4

SNARE zippering

Question 5

What is another name for the 2 Q SNARES?
What is another name for the single R SNARE?

Answer 5

Q SNARES = SNAP-25 + syntaxin
R SNARE = VAMP

Question 6

Where i