Lecture 10 - Pancreas Phys (Also a Pharm Lecture)

Question 1

What are the 4 cell type of the pancreas?

Answer 1

Alpha 2
Beta
Delta
F (PP)

Question 2

What do alpha 2 cells do in the islets of language?

Answer 2

Produce glucagon

Question 3

What do beta cells do in the iselts of langerhans?

Answer 3

Produce insulin

Question 4

What cells produce somatostatin?

Answer 4

delta cells

Question 5

Which transporters move insulin?

Answer 5

GLUT2

Question 6

What stimulates insulin release?

Answer 6

NOT DONE HERE

Question 7

What inhibits insulin release?

Answer 7

NOT DONE HERE

Question 8

What are the major organs for glucose uptake?

Answer 8

NOT DONE HERE

Question 9

GLUT4

Answer 9

Insulin promotes relocations of GLUT4 transporters to the membrane in fat and muscle cells

Question 10

IV or PO glucose shows a greater effect on insulin?

Answer 10

PO since it is activating the incretins in the intestine cells to stimulate the pancreas to release insulin

Question 11

High blood glucose elevates insulin but inhibits _____

Answer 11

Glucagon secretion

Question 12

Hypoglycemia stimulates______

Answer 12

Glucagon release

Question 13

Catecholamines effect on blood glucose

Answer 13

Increase blood glucose by inhibiting insulin secretion

Question 14

Exogenous administration of somatostatin has what effect?

Answer 14

Inhibits release of insulin and glucagon

Question 15

Leptin

Answer 15

Hormone produced in fat tissues to work in the brain to lower appetite

The brain becomes desentsitized to leptin in obese pts

Question 16

What is the effect of exercise on glucose?

Answer 16

Exercise increases the glucose entry into skeletal muscle via increasing GLUT4 transporters

This can precipitate hypoglycemia in DM