Lecture 10: Electrodiagnostic Testing: ERG & VEP Flashcards
what is a full field ERG? What are the 3 types of ERG
- mass response of the entire retina for rod or cone systems
- Photophic negative response (PhNR) - evaluates ganglion cell function
- Pattern ERG (pERG) - evaluates ganglion cell function
- Multifocal ERG (mfERG) - provides topographic mapping of central retina and function of cone system
- mass electrical repsonse of the retina to luminance stimulation
What are the 2 main components of ERG?
- Scotopic (dark adapted response)
- Photopic (light adapted response)
What is visual evoked potential (VEP)?
- function of primary visual pathway at cortical level
- mfVEP
What is EOG?
- electrooculogram - RPE function
What are the 4 types of diopsy vision testing system and what do each of them assess for?
- ffERG - objectively evaluate cone & ganglion cell function
- mfERG - objectivley evaluating localized retinal function
- PERG - objectively evaluating ganglion cell function
- VEP - Protocols for objectively evaluating the function of the entire visual pathway
Scotopic response: first positive b-wave noted is a pure __ response
ROD
(Scotopic response)

Max response to first stimulation is most important in determining between ___ and ___ pathology
photoreceptors, inner layer pathology
(scotopic response)
Negative a-wave assesses what?
photoreceptor function
Postive b-wave assesses what?
Photopic response: negative a-wave assesses what?
cone photoreceptors
Scotopic response: Positive b-wave inner retinal function
__ suppressed by flicker in photopic response
rods
Negative a wave = ____ ; Negative b wave = _____ & _____
- photoreceptor response
- bipolar & mueller cells
Oscillatory Potentials (OP)
- Inner retinal currents from amacrine cells
- Low amplitude wavelets superimposed on ascending B-wave
What is PhNR? (Photopic negative response)
- slow negative component of B-wave of the CONE driven ffERG
- Originates from ganglion cell activity
- depends on intact RGC function
Modest correlation between amplitude of PhNR & thickness of… ? (2)
- peripapillary RNFL
- Ganglion cell layer thickness within the macula
Pattern ERG is generated by the ___ and shows ____.
macula; spatial frequency selectivity
Pattern ERG - retinal response what stimulus?
structured stimulus - reversing black/white checkboard grating
pattern ERG should always be read with ___ or __
ffERG or VEP
Pattern ERG is affected by diseased confined to the __
macula
- will be normal in sever ROD-cone dystrophy with good central VA
- May diagnose diseases that affect only the macula
___ is considered to be one of the best electrodiagnostic tolls for assessment of RGC function
PERG
PERG provides a functional evaluation of the retina __ __ function and __ __ function.
macular cone; ganglion cell
What are the 3 components of pattern ERG?
- Negative (N35)
- Positive (P50)
- Some RGC component
- Negative (N95)
- Large RGC component

Which one is normal and which one is abnormal PERG?

Top normal
- there are glaucoma patients who have abnormal ERG
- P95 amplitude reduction is most significant
In monkeys with bilateral optic atrophy and loss of central RGCs (green trace), the PERG, particularly the
__ component, is substantially reduced while the full-field flash ERG remains normal.
N95
What is mfERG
- Provides topographic mapping of the central retinal function for the cone system
- Diameter of 40-50 degrees
- Allows detection of focal changes in retinal function

mfERG: Amplitude and implicit time of the __component are most commonly used for analysis
P1

Pattern Visual Evoked Potential (pVEP) waveform components include what? (3)
- N75
- P100
- Delay of latency of P100 indicates ON dysfunction involving axon (neuritis or demyelination)
- Decrease in amplitude of P100 is usually due to atrophic changes
- N135
- Changes to the pVEP allow clinicians to place defect at the optic nerve, but it is very general
- We need more specifics for glaucoma… e.g. location within the optic nerve
Complete the chart


Drawback of electrodiagnostic testing
- Some tests are invasive (require electrodes on eye and eyelids)
- Some tests are long (45 to 50 minutes)
- Require consistent protocols and expert interpretation