Lecture 10: Drug Discovery II

Question 1

Mutations in PCSK9 cause

Answer 1

Hypercholesterolemia

Question 2

Desirable LDL value

Answer 2

<130 mg/dL

Question 3

12.1 mmol/L ~

Answer 3

465 mg/dL

Question 4

Individuals with PCSK9 nonsense mutations are

Answer 4

extremely healthy

Question 5

Key player in LDL-C regulation

Answer 5

PCSK9 inhibitors

Question 6

*PSCK9 inhibitor

Answer 6

A fully human monoclonal antibody against PSCK9 blocks PCSK9/LDL-R interaction
-Can no longer bind to LDL receptor
-LDL is fully functional to bind
-No longer have loss of LDL in bloodstream