Lecture 10 Flashcards
Evolution
genetically based change in population properties over time
Mutations that form new alleles
Point mutations, recombination
Mutations that form new genes
Gene duplication, chromosome alterations, polyploidy
Proteins
- Proteins are chains of amino acids
- Proteins have different structures based on amino acid composition and cell environment
- You are largely made up of proteins
- Selection often acts at this level
Nucleotides
-Building blocks of DNA
Purine v. Pyrimidine
- Purines have two ring structures
- Pyrimidines have one ring structures
Transitions v. Transversions
- Transitions are the switching of nucleotides within the type
- Transversions are the switching of nucleotides without the type
- Transitions are more common in evolution than transversions because they maintain structural integrity better (due to similar ring structure)
DNA
- DNA codes for proteins
- DNA replication occurs by separating the helix and creating complementary strands for each template
- A mismatch of complementary nucleotides leads to a point mutation
- Eukaryotic DNA is organized into chromosomes
- Histones have DNA tightly wound around them and condense the DNA into a chromosome
Ploidy
Number of copies of unique chromosomes in a cell; can vary
C-Value
- Measure of the amount of DNA in a cell
- Vary among organisms
- No correlations between complexity and c-value
Transcription
Changing DNA to mRNA
Translation
mRNA to tRNA and the building of proteins from the amino acids attached to tRNA
Uses DNA and RNA polymerases
Gene Expression Regulated
Activators
Transcription factors
Repressors
Types of Mutation
- Point Mutation
- Insertion
- Deletion
- Gene Duplication
- Inversion
- Chromosome fusion
- Genome duplication
Functional Constraint
One constrained strand that keeps the gene functioning