Lecture 1: Pathology Overview Flashcards
What is a disease
Interruption, cessation, or disorder in the function of the body/ organ system
- recognized etiologic agent
- identifiable group of signs and symptoms
- anatomical alterations
6 aspects to the disease process
- Etiology
- Pathogenesis
- Morphological changes
- Clinical manifestations
- Diagnosis
- Clinical course
Etiology definition
The cause or origin of disease
-often multi factorial in origin
Etiology of disease: risk factors
- Congenital: defects that are present at birth, not hereditary
- acquired: defects are caused by events that occur after birth
- genetic predisposition: determined by genes
- environmental: may serve as a trigger to initiate disease process
Examples of biological etiologic factors
Bacterial, viral, fungi
Examples of physical force etiologic factors
Falls, SCI, TBI, burns
Examples of chemical agent etiologic factors
Alcohol, poison
Examples of nutritional excess or depletions etiologic factors
Diabetes, CAD
Examples of genetic abnormality etiologic factors
Cystic fibrosis, sickle cell anemia, hypertension
Pathogenesis definition
How the disease process evolves
Morphological changes in disease process can be __
Gross anatomical and or microscopic
Sign definition and examples
Manifestations of a disease process (can see/measure)
Ex. Elevated temperature, swelling on extremity, changes in skin texture, elevated RR, HR
Symptoms definition and examples
Reported indications of disease perceived by the patient but not observed by others
-subjective complaints such as pain, dizziness, SOB
Syndrome definition and example
Groupings of signs and symptoms that are characteristic of a specific disease state
Ex. Metabolic syndrome
Complications and examples
Adverse extensions of a disease or treatment of a disease
Ex. CAD -> MI -> CHF
Hypertension -> stroke
Medications ->dyskinesia