Lecture 1 - Introduction to Cancer

Question 1

What are the 8 “Hallmarks of Cancer”?

Answer 1

1) Self sufficiency for growth signals
2) Insensitivity to growth inhibitors
3) Limitless replicative potential
4) Sustained angiogenesis
5) Apoptosis avoidance
6) Tissue invasion and Metastasis
7) Abnormal metabolic pathways
8) Immune evasion

Question 2

What are the 3 enabling characteristics to cancer?

Answer 2

1 - Chromosomal abnormalities
2 - Genomic instability
3 - Inflammation

Question 3

Differentiate between an Oncogene and a Tumor Supressor Gene

Answer 3

An oncogene is a gene which increases the susceptibility to cancer when turned on. A tumor suppressor gene increases the susceptibility to cancer when inhibited or destroyed.