Lecture 1: Homeostasis Flashcards
Homeostasis
Maintenance of a constant internal environment via adaptive responses
Characteristics of homeostasis
Optimum concentration, temp, and pressure
Stress
stimuli that messes with constant environment
Cation most abundant EC
Na+
Cation most abundant IC
K+
Anion most abundant EC
Cl-
Feedback loop
Situation where information is constantly being reported to a central control sys
Negative feedback loop
Change in parameter that causes a response to return parameter to normal; stabilizing
Positive feedback loop
Change in parameter that intensifies change to go in same direction; destabilizing
Gain
Degree of effectiveness that a control system maintains constant conditions
Correction
Amount control system is able to counter (Difference between the final conditions)
Error
Amount that could not be controlled by control sys (difference between final and initial conditions in CONTROL sys)
Equation for gain
Gain=correction/error
Separates EC and IC environments
Cell membrane (phospholipid bilayer)
Proteins on either side of membrane or through entirely
Integral protein
Proteins loosely attached to membrane surface
Peripheral protein
Proteins attached to membrane by glycophosphatidylinositol
GPI-anchored proteins (peripheral type)
Membrane component that is not flexible and reduces membrane fluidity
Cholesterol
Plasma membrane functions
- Selective filter
- barrier
- communicates between cell and environment
- endocytosis and exocytosis
Membrane-bound organelles (6)
- Nucleus
- Mitochondria
- ER
- Golgi
- Lysosomes
- Peroxisome and endosomes
Endosome
pinocytosis and phagocytosis; clathrin-coated vesicles form a vesicle around substance that needs to be digested
Digestion mech
(Functions in low ph; has H-ion pumps)
- Lysosome fuses with phagocytic vesicle.
- Whatever is not dissolves (residual body) by lysosome with be exocytosed out of cell
2 organelles who’s function is in synthesis
ER (proteins) and Golgi (lysosomes)
Destinations for protein synthesized from RER with ribosomes attached
Lysosome or secretion
Destinations for proteins synthed on free ribosomes
Mitochondria, nucleus, cytoplasm or other cell membranes
Functions of the Golgi app
- packages protein for secretion
- modifies protein from the RER
- Forms lysosomes
Where is energy produced in the cell? (2)
Cytoplasm (glycolysis) and mitochondria (Krebs and ETC)
Glycolysis
Glc to pyr acid/lactic acid; no oxy; small ATP produced; ctyoplasm
Krebs and ETC chain
Only in mitochondria; Pyr acid to CO2 and H2O; large amount ATP; Oxy is final e- receptor
2 other sources that can be used to generate E
Amino acids and fatty acids to acetoacetic acid which is incorporated into the mitochondria
3 ways movement occurs in the cell
- amoeboid movement (crawling-like; macrophages)
- Cilia (moves materials, ex mucus) and flagella (moves cells)
- Microtubules (tracks for cargo transport)