Lecture 1: Drugs for Sexual Function

Question 1

What 2 parts of sexuality do drugs affect

Answer 1

1. libido

2. performance

Question 2

Male performance: what 3 things do drugs affect

Answer 2

1. erection
2. orgasm
3. ejaculate

Question 3

Female performance: what 2 things do drugs affect

Answer 3

1. lubrication

2. orgasm

Question 4

Testosterone (male + female): incr or decr libido?

Answer 4

Testosterone = incr libido

Question 5

PRL, Estrogen (males) and Serotonin: incr or decr libido?

Answer 5

PRL, Estrogen (males) and Serotonin = decr libido

Question 6

What drug class is used to treat premature ejaculation

Answer 6

Local Anesthetics

Question 7

What are the 2 drugs (one is drug, other is class) that enhance libido

Answer 7

1. Testosterone

2. DA agonists

Question 8

enhanced libido w/DA agonists

- what 3 drugs

Answer 8

enhanced libido w/DA agonists

1. L-DOPA
2. Bromocriptine
3. Apomorphine

Question 9

2 drugs that are used to Tx ED

Answer 9

Drugs that Tx ED

1. PGE1: alprostadil
2. PDE5 Inhibitors: Sildenafil (Viagara)

Question 10

Drugs that Tx ED: PGE1: alprostadil & PDE5 Inhibitors: Sildenafil (Viagara)

what is their MOA (& where) and result

Answer 10

Smooth muscle relaxants in corpora cavernosa –> vasodilation

Question 11

HoTN, Mild penile pain, priapism/prolonged erection are S/Es of what drug

Answer 11

PGE1: alprostadil

Question 12

When is PGE1: alprostadil MC used?

Answer 12

PRE-Viagara

Question 13

PDE5 Inhibitors: Sildenafil (Viagara)

1. How long before intercourse should it be taken?
2. how long is the effective duration?
3. What is true about newer drugs like Tildalfil/Cialis
4. Other than ED what are 2 other uses?
5. Common S/E w/PGE1

Answer 13

PDE5 Inhibitors: Sildenafil (Viagara)

1. take 1 hr before intercourse
2. effective duration = 4 hrs
3. newer drugs like Tildalfil/Cialis = longer eff duration (spp Cilalis = 36 hr)
4. BPH, PAH (pulm arterial HTN)
5. Both PDE5 Inhib + PGE1 causes HoTN

Question 14

PDE5 Inhibitors: Sildenafil (Viagara)

common S/Es (3)
- what are these d/t ?

Answer 14

PDE5 Inhibitors: Sildenafil (Viagara)

common S/E

1. HA
2. flushing
3. indigestion
   - b/c PDE5 Inhib = non-spp vasodilation

Question 15

What is a less common S/E of PDE5 Inhibitors: Sildenafil (Viagara)
- general/spp

Answer 15

Visual disturbances

color/light sensitivity

Question 16

PDE5 Inhibitors: Sildenafil (Viagara)

2 potentially serious S/Es

Answer 16

PDE5 Inhibitors: Sildenafil (Viagara)

Serious S/Es

1. Hearing loss (1 ear)
2. Partial, Permanent Vision Loss

Question 17

What is the name of the vision loss caused by PDE5 Inhibitors: Sildenafil (Viagara)

Answer 17

NAION: Non-arteriotic ischemic optic neuropathy

Question 18

Why should you be worried about giving Sildenafil (Viagara) to pt w/ CVD who is also taking a nitrate? (what 5 things can happen)

Answer 18

Sildenafil (Viagara) + Nitrate –>

1. large drop in BP
2. Syncope
3. Lower cardiac perfusion
4. MI
5. Death in 1st 8 mo of use

Question 19

only FDA approved drug for female sexual dysfunction

- what drug class?

Answer 19

Ospemifene (Osphena)

- SERM