lecture 1- definitions and a brief history Flashcards

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1
Q

what is behaviour?

A

behaviour is anything that a living creature does in reaction to some kind of environmental stimulation

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2
Q

what is neuroscience?

A

neuroscience is the study of the nervous system (the brain, the spinal cord, the sensory/motor neurons) there are multiple approaches to take when studying this area.
-functional: what do these areas do?
-development: how does the nervous system develop over the lifetime?
-anatomically: at the molecular level, the cellular level, the level of different brain regions and structures
-medical: what happens when things go wrong, and how can they be treated?

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3
Q

heart or head?

A
  • 2780 BCE: egyptian medical records
  • links injuries to the head with deficits in the body
  • against the key theory of the time
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4
Q

what is the cardiocentric model?

A

the heart is the key organ of the body

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5
Q

the Hippocratic revolution 5th century BCE - 348 BCE

A
  • Alcmaeon (5th century BCE): the brain as the site of sensation and thought
  • Hippocrates (460-370 BCE): the brain is controlling organ of the body
  • Plato (428-348 BCE): the triune soul- brain, heart and gut
    -the brain= intellect
    -the heart= anger, fear and pride
    -the gut= greed, desire and lower passions
  • the intellectual soul (that in the brain) is immortal
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6
Q

Aristotle 384-322 BCE

A
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7
Q

but why aristotle?

A
  • observations limited to animals
  • the majority of which were cold-blooded
  • and small
    -no clinical experience
  • a ‘pure’ biologist, rather than an applied one
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8
Q

Galen 130-200 AD

A
  • the most influential physician of the roman empire
  • dissected a wide range of animals including mamals
  • the first to number the cranial nerves, and suggest some might be motor functions and some for sensory functions
  • sensation and perception results from the conversion of vital spirits (in the heart) into animal spirits (in the brain)
  • these spirits flow through the nerves and cause action/sensation
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9
Q

Galen and localisation

A

-the basic components of intellect: imagination/perception, cognition and memory
-these components were dependant of each other
-but for now, no further attempt at localisation

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10
Q

Bishop Nemesius and the ventricular doctrine (360 AD)

A
  • suggested the ventricles as the home of the three components
    • perception= anterior ventricle
    • cognition= middle ventricles
    • memory= posterior ventricles
  • widely accepted idea
  • supported by early dissociation studies
    • damage to specific region= loss of that function
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11
Q

the renaissance and hands on experience

A

-Andreas Vesalius (1524-1564)
-anatomist and author
- studied in Padua: access to human bodies
-highlighted multiple instances where the human brain did not fit Galens descriptions
- urged study of anatomy via dissection
- rejected the ventricular doctrine

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12
Q

localisation in the spinal cord- what two types of nerves does the spinal cord have emerging from it?

A

-Dorsal (posterior) nerve: carries sensory information into the spinal cord
-Ventral (anterior) nerve: carries motor signals to the muscles to produce movement

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13
Q

the bell-Magendie law

A
  • Bell (1774- 1842): motor functions of the ventral roots
  • Magendie (1783-1855): sensory functions of the dorsal roots
  • The bell-magendie law:
  • the anterior nerves contain only motor fibres, the posterior roots only sensory fibres
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14
Q

Franze Gall (1758-1828) and extreme localisation

A
  • regions of the brain relate to specific functions and traits
  • greater skill= larger area/development
  • greater development in the brain= matching development in the skill
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15
Q

phrenology

A
  • the more spiritual the trait, the higher on the skull it is
  • destructiveness: indicated by development above the ear
    -apothecary turned executioner
    • also. wild animals
      -acquisitiveness: upper front of the squamous structure
    • well developed in pickpockets
      -early pop psychology
      -and quickly commercialised
  • and a component of 19th century scientific racism
  • remnants of phrenology in modern phrases
    • highbrow vs lowbrow
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16
Q

cortical equivalence

A
  • marie-jean-pierre flourens (1794-1867)
    -the cortex function as a whole
  • all parts are responsible for intelligence, the will and perception
  • animals studies: subjects recover abilities after destruction of cortical areas
  • animal subjects; eg frogs, hens
    • lower cortical dependency
      -use of younger subjects
      -greater possibility?
  • possibility of bias in interpretations?
17
Q

the shift towards localisation

A
  • paul broca and patient tan (1861)
  • left inferior frontal cortex damaged
    • language understanding: functional
    • language production: impaired
  • evidence for localisation of language functions… accepted?
  • paul Broca
    -right person, right time
  • no previous ties to phrenology
  • proposed site did not fit with phrenological theories
  • an extremely detailed case study provided
18
Q

phineas gage - pre accident

A
  • pre accident: railroad construction foreman
  • seen as responsible, intelligent, social
  • 1848- blasting accident: damage to frontal cortex
19
Q

phineas gage- post accident

A
  • changes in personality
  • unreliable, disrespectful, lost his sense of social conventions and responsibility
  • ‘no longer gage’
20
Q

phineas gage

A
  • evidence for localisation of function:
  • the index case for personality change due to frontal lobe damage
  • initial reports on his case:
    -no mention of cognitive changes- (harlow,1848)
  • ‘the patient is not well’- (Bigelow, 1848)
21
Q

the importance of primary sources

A
  • initial support for theories of cortical equivalency
  • support for theories of localised function
  • early evidence for psychosocial adaptation/social recovery?
22
Q

cytoarchitecture

A
  • theodor meynery (1833-1892)
  • the cellular architecture of the brain
  • noted variations in the historical structures, according to the regions (1876)
23
Q

visualising cells

A
  • Franz Nissl (1860-1919): The Nissl method
  • stains the cell body highlighting different structures
  • allowed examination of internal cell details
24
Q

visualising cells cont.

A

-Camillo Golgi (1843-1926)
- silver nitrate staining solution
- stains selected cells in their entirety
- visualising of axon, dendrite, and the length of neuron possible

25
Q

neuron doctrine

A
  • santiago ramon y cajal (1852-1934)
  • modification of the golgi stain
  • nerve cells are individual structures
  • no physical connection between them
26
Q

neuron doctrine (1906)

A
  • the brain is made up individual units (cells)
  • units are specialised depending on function
  • they are connected by sites of contact (the synapse), not shared cytoplasm
  • each synapse releases only one type of transmitter
  • updates
  • electrical synapses: are connected by cytoplasm
  • contransmission is very common
27
Q

localisation: where are we now?

A
  • brain regions can be related to specific functions/behaviours
  • but no one part of the brain is an island
  • vast interconnections between the regions and structures
  • the connections are similarly important in understanding how behaviours may be affected/controlled
  • neither extreme view suits what we observe- and other factors will influence behaviour and development as well
28
Q

what are the 3 recent ideas in biological psychology?

A
  • lateralisation of functions
  • neuroplasticity
  • neuroethics
29
Q

lateralisation of function

A
  • localisation of certain functions to either the left or right hemisphere
  • broadly:
  • language localised to the left hemisphere (LH)
  • face recognition localised to the right hemisphere (RH)
  • emotion localised to the RH
30
Q

neuromyth: left brain vs right brain

A
  • extreme lateralisation:
    • left hemisphere= rational/logical/masculine
    • right hemisphere= creativity/intuition/feminine
  • educational programs
    -right brain dominant children
    • require different styles of teaching

-evidence
- little to suggest anything as extreme as this division