lecture 1/2 Flashcards
Genes come in multiple
forms called…
alleles
Genes are located on…
chromosomes
Genetic information is…
transferred from DNA to RNA to protein
meiosis 1
segregate the homologous chromosomes
meiosis 2
separate the sister chromatids
Null/Amorphic Alleles
A nonfunctional protein is produced OR no protein is produced
Hypomorphic Alleles
A poorly functioning protein is produced OR reduced amounts of a normally functioning
protein is produced 39
multiplication rule
and
addition rule
or
Dominant Mutations Often Involve…
Gain/Change of Gene Function
Recessive Mutations Often involve…
loss of gene function
Dominant Hypermorphic Alleles
- Negative phenotypic consequences due to the over- production of a normal protein OR
- Negative phenotypic consequences due to the production of a protein with increased activity levels
Neomorphic Alleles
- Negative phenotypic consequences due to the presence of an altered protein that has a new function
- Negative phenotypic consequences when the altered protein interferes with the wildtype protein (Dominant-negative allele)
For traits that are rare and dominant, affected
individuals are most likely to be…
heterozygous