Lecture 1 Flashcards
What is ideal state for cell function?
Liquid crystalline
Amphipathic
hydrophilic head with hydrophobic tail
Amphipathic
hydrophilic head with hydrophobic tail
why is liquid crystalline ideal?
cell membrane is fluid and adaptable to environmental changes
4 factors that alter membrane fluidity
Fatty acid chain length, Saturation, Head composition, Cholesterol
Fatty acid chain length
long-low fluidity short-high fluidity
Saturation
Unsaturated- high fluidity(more Kinks for particles to slip through) Saturation- low fluidity (more rigid)
Head composition
PC - cylindrical, closer together lower fluidity
PE - conical, further apart higher fluidity
Cholesterol
More cholesterol equals more fluidity
Homeostatic changes
Response in phospholipid composition to environmental temperature changes
Lipid raft
Accumulated glycogen and cholesterol
Low temperature effect on fluidity
Low temperature leads to higher fluidity because cold causes gel state, systems must respond with increased fluidity
High temperature effect on fluidity
High temperature causes higher fluidity, so systems change to lower fluidity
18 2n-3 nomenclature
18 - # of carbons
2 - # of double bonds
N - 3 - location of first double bond
Double bond effect on fluidity
(unsaturated), causes kinks in lipid tail and increases fluidity