lecture 1

Question 1

skin receives ___ of resting CO

Answer 1

1/3

Question 2

functions of the epidermis

Answer 2

barrier, regulate fluid, light touch, thermoreg, assist w excretion, vit D, cosmetic appearance and communication

Question 3

types of epidermal cells

Answer 3

keratinocytes
melanocytes
merkel cells
langerhans

Question 4

keratinocytes are

Answer 4

90%: main cell of re-epithelialization

Question 5

merkel cells help with

Answer 5

light touch sensation! mechanoreceptors

Question 6

langerhan’s cells are

Answer 6

derived from bone marrow, immune!!!

Question 7

dermis does what?

Answer 7

nourishes epidermis
houses epidermal appendages
assists with infection control
assist w thermoreg
provide sensation

Question 8

dermis is vascular or avascular?

Answer 8

vascular

Question 9

what are blisters?

Answer 9

junction of the papillary dermis and the stratum basale when there is friction; this area is called rete ridges

Question 10

mast cells do what?

Answer 10

director/waves flags! defense cell that produce chemical mediators of inflammation such as histamine

Question 11

adipose tissue is what?

Answer 11

highly vascular connective tissue
provides cushion, stores energy
looks shiny white or yellow balls

Question 12

what are types of subcutaneous tissue

Question 13

skin is very fragile even after wound closes. How long does it take to heal?

Answer 13

2 years and only 80% of strength

Question 14

MMPs do what?

Answer 14

general contractor!
1. remove damaged ECM/bacteria in inflammation
2. proliferation= latticework for angiogenesis
3. remodeling = contraction of scar ECM
too many MMPs= nothing gets done! wounds become chronic

Question 15

wound is electropositive and this is good or bad? why?

Answer 15

starts wound healing cascade!

Question 16

primary closure

Answer 16

wound is cleaned and edges are physically approximated and fixed (sutures/staples)

Question 17

secondary closure

Answer 17

wound left open, follows three phases of wound healing to close

Question 18

wound that is chronic is defined as

Answer 18

-medicare: wound that does not heal in 30 days
-definition: stuck in a phase

Question 19

senescent cells

Answer 19

take up resources, do not contribute
present in chronic wounds

Question 20

chronic wounds have

Answer 20

senescent cells
greater bioburden
higher levels of MMPs
biofilm present

Question 21

induration is

Answer 21

thickening/hardening