Lecture 1 Flashcards
Chronobiology
The systematic scientific study of living timing processes in plants and animals.
Jean Jacques (1729)
Even without sunlight, his plants open their leaves by day and close them at night
Circadian Rhythm
Cycle of various metabolic, chemical, endocrine & behavioural processes, alternately through high and low activity phases with a periodicity of ~ 24 hrs.
Daily rhythms
Patterns of behaviour, physiology, and biochemical patterns in humans
Circadian regulation organizes crucial yet potentially conflicting processes. Therefore, it has to be:
- Persistent (self-sustained) in the absence of environmental cues
- Robust (in dynamic circumstances, buffered against inappropriate signals)
- Entrainable but also able to free-run at periods slightly different than 24h
Actigraphy
the method of collecting data on activity and sleep-wake patterns
Free-running period
internal period without limitation
Lobban (1957) Spitsbergen Study
Study on Forced desynchronization of 27 hours. Found that:
- Urinary flows follows sleep-wake
- Potassium excretion follows 24-hour rhythm
- Differential influence of endogenous vs exogenous cues.
What pattern does Urinary flows follow?
Sleep-wake
What pattern does Potassium excretion follow?
Circadian Rhythm
Forced desynchronization
behavioural rhythm is desynchronised to the internal rhythm .
Circadian Time
subjective internal organism time. In free running conditions, its endogenous rhythm is not 24 hours
A circadian hour
FRP/24
CT0 / CT12
- CT0 = subjective dawn
- CT12 is subjective dusk
Endogenous rhythm
Rhythm that continues even in the absence of any external cues.
Exogenous rhythm
a rhythm that occurs only in response to external cues.
The circadian principle
The longer we are active, the shorter we sleep
The homeostatic principle
The longer (and more) we are active, the deeper we sleep
Self-reported fatigue does not increase linearly over the day, but in sine-wave form. How is this?
Increasing sleep pressure during the day is (initially) counteracted by increasing wake signal but towards the end of day, both processes strengthen each other, then at night, fast decreasing sleep drive is counteracted by low wake drive.
What drives the Circadian process?
The Suprachiasmatic Nucleus
What pattern does melatonin flows follow?
circadian rhythm
What pattern does core body temperature flows follow?
circadian rhythm
What pattern does subjective alertness flows follow?
circadian rhythm
What is melatonin?
a hormone synthesized and secreted by the pineal gland, - Peaks during subjective night, enables good sleep (initiation and consolidation)