Lecture #1

Question 1

Pharmacogenomics

Answer 1

using genomic approaches to identify genetic factors that are able to distinguish patients with different responses to a drug, and translate these findings into patient treatment
the goal of PGx practice is to offer the right drug at the right time with the right dose to the right person

Question 2

Many actionable signatures have been revealed

Answer 2

actionable signature: information used to make treatment decision
genetic markers can distinguish patients: who are most likely to respond to a drug, who are most likely to develop side effects, who should not take a drug, the best dose to be taken
FDA has approved ~ 150 pharmacogenomic drug labels as of 2018

Question 3

Genetic factors are involved in both PK and PD

Answer 3

PK: what the body does to the drug - ADME: absorption, distribution, metabolism, excretion
PD: what the drug does to the body: receptor, target, signaling, enzymes

Question 4

Pharmacists’ role

Answer 4

recommending
designing
educating
communicating

Question 5

Pharmacists; role: recommending

Answer 5

recommending (or scheduling) pharmacogenomic testing to aid in the process of drug and dosage selection

Question 6

Pharmacists’ role: designing

Answer 6

designing a patient-specific drug and dosage regimen based on the patient’s pharmacogenomic profile that also considers the PK and PD properties of the drug

Question 7

Pharmacists’ role: educating

Answer 7

Educating patients, pharmacists, and other health care professionals about pharmacogenomic principles and appropriate indications for clinical pharmacogenomic testing

Question 8

Pharmacists’ role: communicating

Answer 8

Communicating pharamcogenomic-specific drug therapy recommendations to the health care team, including documentation of interpretation of results in the patient’s health record