Lecture 1 Flashcards

1
Q

Homeostasis

A

A Healthy Balance.
pH 7.4
Temp 34 degree C

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2
Q

Extracellular Fluid

A

-Underneath Skin and Between Cells
-Content of Cells Living Conditions

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3
Q

Intracellular Fluid

A
  • Internal Environment of Cells
  • Contents of the cell.
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4
Q

Homeostasis Lungs

A

-CO2 removal
-Acid/base buffer (temp)

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5
Q

Homeostasis GI System

A

-Nutrients and Volume
-Origins of ECF
-gets rid of waste

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6
Q

Homeostasis Kidney

A

-Tight Control of Electrolytes
-Acid/ Base Volumes
-Pressures in the Circulatory System

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7
Q

Homeostasis Liver

A

-Get rid of “bad”
-Using Chemical Runs to change the structure and natural waste

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8
Q

Homeostasis Peripheral Vascular Bed

A

-High Speed portion of ECF
-Blood Volume 5L/min
-CO 5L/min (rest)
-30-40 L/min with activity

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9
Q

Homeostasis Capillaries

A

-oxygen making its way out of tissues
-waste products going back into circulatory system; usually by diffusion
-diffusion is slower than pumping blood around circulatory system

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10
Q

Negative Feedback

A

The Process our body uses to control most of our functions
1.) Sensor
2.) Thinking/Integrate (Brainstem)

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11
Q

Negative Feedback Example (BP)

A

BP setpoint is 100. Barocreptors look at this pressure. BP increases, baroreceptors send that info to the nervous system. Nervous system will react to bring the BP back to 100.

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12
Q

Negative Feedback (Pulmonary)

A

CO2 increases. Body caused an increase in ventilation. Causing the CO2 to decrease.

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13
Q

Vicious Cycle

A

-Positive feedback gets in a vicious cycle until the death of a patient.
-When positive feedback goes wrong.

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13
Q

Positive Feed Back Definition

A

-Involves a change and amplification -of the change
-used less than negative feedback

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14
Q

Positive Feed Back Example (Good)

A

Oxytocin is released. Cervix stretches. Telling the brain to release more oxytocin. Continues until birth.

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15
Q

Positive Feed Back Going bad

A

-Blood Clotting Cascade that doesn’t terminate with control of bleeding
-Results in vessels clotting off
-Resulting in Heart attack d/t no perfusion

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16
Q

Positive Feedback:
Sepsis/Necrosis

A

-Cells unable to work b/c the environment around them in collapsing and not improving

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17
Q

Positive Feedback:
Severe Acidosis

A

-Depresses CNS, Causing more acidosis
-Depresses Respiratory Drive

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18
Q

Positive Feedback:
Peripheral Acidotic Conditions

A

-Decrease in percussion to the leg
-Body unable to clear the acidosis
-Causing healthy tissue to die

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19
Q

Positive Feedback:
Atheroscleric Plaque Clotting

A

-Coagulation Cascade union the point of no shutdown

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20
Q

Postive Feedback:
Diabetic Renal Inflammation/Hyperfiltration

A

Born with 200 million nephron. The more we age and lose nephrons, causing more work for other nephrons. Aging them faster.

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21
Q

Postive Feedback:
Sever Hemorrhage

A

Low BP, causes low CO. Aorta pressure low. Coronary blood vessels pressure low. Continuing and weakening the heart until heart failure.

22
Q

Compensated Shock

A

-Negative Feedback works well
-You can lose 20% or 1 L of blood and the body will compensate, regenerate and return to normal over time.

23
Q

Decompensated Shock

A

-Positive Feedback leads to death, negative feedback insufficient.
-Lose 20% or 2L of blood, the body can not compensate without assistance such as transfusion.

24
Q

Changes in Physiologic Systems

A

-Can alter drug responses
-Can also be altered by drugs
-we are never as good at fixing the body as the body itself

25
Q

Cells

A

-Smallest living unit
-Able to survive on their own in a good environment
-Have some ability to replicate themselves

26
Q

RBC

A

Do not have DNA in nucleus

27
Q

Cell Membrane

A

-Phospholipid bilayer made up of small fatty layers that keep charged material into or outside the cells.

28
Q

Cytoplasm

A

Water outside the nucleus, internal bulk of the cell and everything dissolved in the water

29
Q

Internal Mass of a cell

A

70-85% water

30
Q

Adipose Tissue

A

5-10% water

31
Q

Steroids

A

Act on the nucleus and turn on genes to respond to stress

32
Q

Pores

A

Picky about what they let into the cell

33
Q

DNA

A

-In strands when resting in the cell, Only in the contained state when dividing
-Contains all instructions for life
-Codes for proteins and lipids

34
Q

Proteins

A

-Can be structural or enzymes
-Specialized for specific tasks

35
Q

Golgi Apparatus

A

-Short Distance from Rough ER.
-Proteins that need to be modified hang out in ER vesicles.
-Folds Proteins into modifications for the body

36
Q

ER Vesicles

A

Transport vesicles that help shift protein precursor over to the Golgi apparatus

37
Q

Rough ER

A

Embedded in machines called Ribosomes to produce proteins

38
Q

Smooth ER

A

Produces Lipids

39
Q

Nucleus Wall

A

Is continuous of ER

40
Q

MRNA

A

-Contains instructions to make such things such as proteins.
-Made in the ER

41
Q

Proteins

A

-Long Chain of Amino Acids
-shaped at the Golgi apparatus for their purpose

42
Q

Translation of Proteins

A

DNA -> mRNA -> Ribosomes -> Proteins

43
Q

Cell Components: Water

A
  • All of items that are inside a cell are dissolved in water
    -Charged/polar items
    -Water has 2 pairs of electrons that are assessable to other protons
    -Protons helped to determine pH
44
Q

Cell Component: Organelles

A

Small, specialized locations in cells (transport vesicles, etc)

45
Q

Cell Components: Enzymes

A

-Made of Proteins
-Catalyze Chemicals (ex: Ribosomes Receptors)

46
Q

Cell Components: Protein

A

-Can Either do work (Be enzymes)
-Or be structural things

47
Q

Cell Components: “Sugar” “Glycol”

A

-Sugar added to Protein. Ex: HGB A1C
-Happens at Golgi apparatus

48
Q

Cell Component: Lysosome

A

-digestive using acid hydrolysis
-pH 4.5 - 5.0 (acidic)
-hydrolysis enzymes
-destroys foreign invaders/garbage collectors

49
Q

Cell Component: Peroxisomes

A

-Oxidative stress to remove/destroy
-Ex: Liver metabolizes alcohol
-Fat metabolism, destroys bacteria and Viruses
- Buds off Smooth ER

50
Q

Cell Components: Mitochondria

A
  • Hangs around in Cytosol
    -Creates ATP
    -Requires oxygen
    -Creates 1 ATP/ glucose molecule
    -Self Replicating/has own DNA
51
Q

ATP

A

-Total of 38 per cell
-36 in mitochondria (oxygen required)
-2 in glycolysis (No oxygen)

52
Q

Peripheral circulatory system

A

-Example of Homeostasis
- Supplies oxygen, glucose, nutrients
-Removes CO2, protons, metabolic waste products.