lecture 1 Flashcards
antibody formation: what does IgM and IgG show?
IgM: recent infection
IgG: Latent infection: higher in secondary response
Innate Immunity
Response is fast and non specific. No memory. Has neutrophils, macrophages, dendritic cells, NK cells and complement
Adaptive Immunity
Response is slow on first exposure, momory response is fast. Has T cells, B cells abd circulating antibodies.
can lead to autoimmunity. provides high affinity receptors for antigens
Thymus
produces T Cells: life long adaptive immunity
Bone marrow
produces B cells
Immunization Natural passive
maternal ( moms milk) short term
immunization Natural active
infection creates memory that last life long
immunization Artificial Passive
antibody transfer
Immunization Artifical Active
immunization ( flu shot)
DAMP
danger signal, damage signal
PAMP
absolutely required for pathogen survival. ex endotoxin
Toll-like receptor
innate immune system, reconizes microbes, activates immune response. PAMPS. join together with interlukins. SENSORS FOR PATHOGENS
macrophages, monocytes, and dendritic cells make what?
interleukins
Immune cells can produce signalling factors called cytokines, which trigger ____?.
inflammation
inflammation induced by endotoxin is an example of
PAMP