Lecture 1 Flashcards
Pharmaceutical Chemistry
To synthesize active pharmaceutical ingredients
Pharmaceutical Engineering
To produce dosage forms for maximum drug stability and efficacy
Pharmaceutical Biology
to connect drug, cell, and body
Properties to maximize API Stability
Particle size change in suspensions, phase transition, and crystal growth from liquids or amorphous formulations
What does ADME stand for?
Absorption, Distribution, Metabolism, and Elimination/Excretion
Conversion of molecular concentration to mass concentration
Molar concentration x MW
Conversion of mass concentration to molecular concentration
Mass concentration x MW
BCS Class 1: ____ Permeability and ____ Solubility
high, high
BCS Class 2: ____ Permeability and ____ Solubility
high, low
BCS Class 3: ____ Permeability and ____ Solubility
low, high
BCS Class 4: ____ Permeability and ____ Solubility
low, low
Oxidation is characterized by a loss of ____ or ____
hydrogen, oxygen
Oxidation is catalyzed by these metal ions (2)
Fe & Cu
First assumption for the rates of reactions in transition state theory
In order for the initial state to be transformed to the final state, the must first pass through an intermediate transition state that is of higher energy than the initial and final states.
Second assumption for the rates of reactions in transition state theory
The molecules in the transition state are in equilibrium with those in the initial state
