lecture 1 Flashcards
What are the types of metabolic control?
compartmentatuon
coordination of anabolic and catabolic processes
allosteric control
hormonal regulation
Why are fats more efficient than sugar or amino acids?
More reduced and than sugar and amino acids, yield 9kcal/gm. Does not require water,
Why are fats better for long term storage?
TAGS pack closely together excluding water
What are lipid droplets?
organelles filled with TAGs and CE surrounded my a phospholipid monolayer
How do we emulsify fats? What is the purpose?
Use bile salts (surrounded by cholate), break down fats with bile salts to increase available surface area for HPL
What is bile? Where is it secreted from?
Bile is bile salts, cholestrol phosphatidylcholine and is secreted by the liver and gallbladder
What is a mixed micelle?
lipid core with bile salt, phospholipid exterior
What is pancreatic lipase?
hydrolyzes TAG esters by working at the lipid water interface
How does HPL interact with collapse?
lid flips, exposes catalytic triad to bind collapse, causes conformational change to make hydrophobic patch that fits into mixed micelle monolayer
How do FFA act inside a cell?
They go through a transporter and use FABP to solubilize fatty acids with a protein shell
How do we inhibit pancreatic lipase?
Orlistat binds covalently to catalytic serine
What are the side effects of orlistat?
more dietary fat can reach your intestine, more microbe in intestine, reduced fat absorption
