Lecture 1

Question 1

What is Genomics?

Answer 1

the study of genomes

Question 2

What is a Genome?

Answer 2

The totality of DNA in a cell

Question 3

Genetics

Answer 3

is the study of heredity, how characteristics are transmitter from one generation to the next via DNA. Genetics scrutinizes the function and composition of individual genes

Question 4

Genomics

Answer 4

studies the entire genome, all of the organism’s genes, and how they interact. examines the features and dynamics of the genome itself

Question 5

what is the size (in basepaires) of the human genome?

Answer 5

3.2 billion base pairs (3.2 Gb)

Question 6

what is the size (in meters) of the human genome?

Answer 6

3 meters

Question 7

how much of this encodes protein-coding genes?

Answer 7

only 1-2%

Question 8

how much of the genomes has any function?

Answer 8

probably only 5-10%

Question 9

what is a chromosome?

Answer 9

a continous thread of dna in a cell or nucleus

Question 10

how many chromosomes are in the human genome?

Answer 10

46 (22 pairs are autosomes, +1 pair of sex chromosomes)

Question 11

History of genomics
-1871

Answer 11

friedrich miescher publishes his paper identifying the presence of “nuclein” (not known as DNA) and associated proteins, in the cell nucleus.

Question 12

1904

Answer 12

Walter Sutton and theodor boveri proposes the chromosome theory of heredity after finding that chromosome occur in matched pairs, one inherited from the mother and one from the father

Question 13

1910

Answer 13

albrecht kossel is awarded the first nobel prize in physiology or medicine for his discovery of the five nucleotide bases, adenine, cytosine, guanine, thymine, and uracil.