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Coag Lect Final > Lect Final 86% > Flashcards

Lect Final 86% Flashcards

1
Q

Infant Sample collection

A
  • Must minimize the amount of sample drawn, due to small blood volume in infants
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2
Q

“Well” infants experience

A

– Immune thrombocytopenia, vitamin K deficiency,
hemophilia, bleeding from a localized vascular lesion

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3
Q

sick infants

A

– Prematurity, perinatal infection, respiratory distress
syndrome, metabolic derangements, birth asphyxia
▪ DIC, liver failure, isolated platelet consumption defect

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4
Q

Identifying aPL Antibodies

A
  1. Prolongation of a PL-dependent coagulation test (e.g.,
    APTT, dRVVT, KCT)
  2. Evidence of inhibitor activity (lack of correction by a 1:1
    mix with normal plasma)
  3. Confirmation that inhibitory effect blocks PL-dependent
    coagulation (i.e., neutralization of inhibitor effect by
    addition of excess PLs or changing PL source)
  4. Absence of specific inhibitor against a coagulation factor
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5
Q

Antiphospholipid Antibody Syndrome
(APLS

A

-Not clearly understood
-presents as VTE (DVT, PE), arterial thromboses (stroke, TIA, MI)
- recurrent miscarriages

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6
Q
  • Antiphospholipid antibodies
A

▪ Lupus anticoagulant (LA)
▪ Anticardiolipin antibodies (aCL)
▪ Several subgroups—antibodies to PLs and PL binding
proteins

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7
Q

negatively charged surface

A

repels platelet and hemostatic proteins

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8
Q

heparan sulfate(HS)

A

inhibits fibrin formation - cofactor for antithrombin

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9
Q

thrombomodulin(TM)

A

binds thrombin and enhances activation of protein C

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10
Q

endothelial protein C receptor

A

binds protein C and facilitates PC activation

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11
Q

Tissue Factor pathway inhibitor TFPI

A

Binds TF/FVIIA/FXa complex
inhibits extrinsic pathway of coagulation

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12
Q

Postacyclin PGI2

A

promotes vasodilation, inhibits platelet activation

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13
Q

Tissue plasminogen activator tPA

A

activates fibrinolysis system

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14
Q

Annexin A2 -tPa receptor A2

A

binds tPA and plasminogen, activates finbrinolysis

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15
Q

Urinary type plasminogen activator

A

binds uPAR and plasminogen, activates fifrinolysis

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16
Q

Nitric oxide NO

A

promotes vasodilation, inhibits platelet recruitment and accumulation

17
Q

ADPase CD39

A

degrades ATP and ADP to AMP anf adenosine

18
Q

Endothelin ET

A

promotes vasoconstriction

19
Q

vWF

A

carries FVIII in plasma, facilitates platelet adhesion

20
Q

tissue factor TF

A

initiates fibrin formation, activates FVII

21
Q

plasminogen activator inhibitor PAI-1

A

inhibits activation of fibrinolysis

22
Q

what activates fibrinolysis

A

tPA, A2, uPA, uPAR

23
Q

what is the difference btwn resting endothelium and activated

A

answer in book

24
Q

what are the 2 membrane systems

A

open canalicular
dense tubular

25
Q

open canalicular

A

originate from invagination of plasma membrane
- provides route for substances entering and leaving platelet
- secretion of granule contents

26
Q

dense tubular

A

originates from endoplasmic reticulum of MK
-storage site for Ca++
-major site for prostaglandin and TXA2

27
Q

what is in organelle zone

A

mitochondrion, a-granule, lysosome, dense granule, glycogen

28
Q

dense granules

A

non-protein mediators( ADP/ATP, Ca++, serotonin,

29
Q

α-granules (αG)

A

most numerous, Contain hemostatic/inhibitor/adhesive proteins
protein mediators

30
Q

lysosomes

A

has hydrolytic enzymes
and the release is associated with strong platelet agonists

31
Q

peroxisomes

A

fatty acid oxidation and synthesis of platelet activating factor (PAF)
-lipid metabolism

32
Q

mitochondria

A

oxidative energy metabolism

33
Q

what does the pheripheral zone consist of

A

membrane and glycocalyx

34
Q

Glycocalyx (surface coat)

A

Responsible for negative charge of platelet surface
Some proteins act as receptors for platelet activation

35
Q

plasma membrane

A

phosopholipid bilayer
Asymmetric arrangement
Contains integral proteins–>Receptors for VWF, fibrinogen, collagen, thrombin, fibronectin, and vitronectin

36
Q

structural zone

A

actin(g and f forms)
microtubles
submembranous cytoskeleton
myosin

37
Q

reciporal protease

A

factor 12 and PK

Coag Lect Final (1 decks)

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