lect 3 wk 1 term 4

Question 1

How CCL4 exposure results in cellular injury?

a. mitochondria destruction
b. ER damage
c. plasma membrane
d. nucleus

Answer 1

B. ER
CCL4 changes into CCL3 radical that affects the ER membranes, resulting in decline in protein synthesis and swelling of ER.

CCl4 is banned from the dry cleaning industry but was prevalent previously.

Question 2

What is the term used for nucleus shrinkage in irreversible cell injury?

1. Karyolysis
2. Pyknosis
3. karyorrhexis

Answer 2

2. Pyknosis.

Question 3

What is the term used for fragmentation of nucleus resulting from irreversible cellular injury

1. Karyolysis
2. Pyknosis
3. karyorrhexis

Answer 3

3. Karyorrhexis

Question 4

What is the term used for dissolution of nucleus fragments resulting from irreversible cellular injury?

1. Karyolysis
2. Pyknosis
3. karyorrhexis

Answer 4

1. Karyolysis

Question 5

When would you see BAX and BAK active.

a. Necrosis
b. Apoptosis

Answer 5

b. Apoptosis

BAK and BAX are BCL2 family effectors and promote execution of apoptosis.

Question 6

What is the difference between coagulative and liquefactive necrosis

Answer 6

Coagulative necrosis: architecture of the cell is preserved and has no superimposed infections, where as liquefactive necrosis, there is superimposed infection resulting in inflammatory mediated tissue digestion (liquification)

Question 7

What is common between pancreatic fat tissue and breast tissue?

Answer 7

Upon injury, both tissues make SOAP: Calcium combined with fat called sapnofication resulting in fat necrosis.