Lec3 Flashcards
What is the primary purpose of a disintegration apparatus in suppository testing?
To assess the melting behavior of suppositories
Which of the following is a characteristic of a good suppository?
Hardness between 600 – 1400 g
What happens to a suppository that cannot withstand a weight of 600 g for 1 minute?
It is rejected
During the melting test, when is the melting considered complete?
When no fragments remain on the screen
What is the significance of the hardness range in suppositories?
It influences the handling and stability
Which of the following is NOT a visual examination criterion for suppositories?
Weight variation
What is the acceptable percentage deviation for the weight of suppositories?
5%
In dissolution testing, what method is used to determine drug content?
UV spectrophotometry
What is the purpose of taking aliquots during dissolution testing?
To determine the drug release pattern
Which of the following bases is commonly used in suppository formulation?
A) Glycerol-gelatin
B) Polyethylene glycol
What is the first step in the operation of the hardness test for suppositories?
Place the suppository on the upper disk
What is the consequence of a suppository being too hard (>1400 g)?
It will not soften or dissolve inside the body
How long should the hardness test be conducted for each interval?
60 seconds
What is the main advantage of using vaginal suppositories?
They provide localized treatment
What should be checked during the visual examination of suppositories?
The absence of sedimentation
What is the role of the plastic disc in the melting test?
To hold the suppository in place
What is the purpose of the weight variation test?
To ensure uniformity in dosage
Which of the following statements is true regarding suppository shapes?
Different shapes have different breaking points
What is the main factor that influences the melting range of a suppository?
The shape of the suppository
What is the primary focus of the Course Learning Outcomes (CLOs) mentioned in the document?
To describe the procedures for preparing various dosage forms
