Lec2 Methods for assessing psychological dysfunction Flashcards

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1
Q

what are the aims of assessments

A

i. Clinical decision making 1. Diagnostic, prognosis, treatment and follow-up ii. Research into disease mechanisms iii. Understanding normal psychological function iv. These aims are interdependent

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2
Q

what are the two comparison standard used in assessments? give an example of each

A

a) Normative comparison standards use as a baseline the population average i. i.e. Bells or letter test in spatial neglect b) Individual comparison standards use as a baseline individual’s own earlier performance i. i.e. Hamilton or Beck depression scales

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3
Q

Pros and cons of standardised tests (normative comparison standards

A

Advantages i. Diagnostic value Disadvantages i. collecting control data is laborious ii. the normal distribution may differ depending on the characteristics of the population iii. not all psychological variables are normally distributed iv. not all psychological variables are easy to measure

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4
Q

Rating scales are useful for ______________

A

Rating scales do not confirm diagnoses. they are used to monitor suspected or diagnosed deficits. they are part of the evaluation and management of disease, and are useful for measuring responses to treatments

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5
Q

Describe the content of Beck Depression scale

A

21 questions about how the subject has been feeling last week. Each question has a set of at least four possible answer choises ranging in intensity

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6
Q

Pros and cons of rating scales (individual comparison standards?

A

Advantages 1. Easy and cheap 2. Can be used for variables that are not normally distributed or are difficult to measure Disadvantages 1. Risk of operator error 2. the pitfalls in ‘self-reporting’

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7
Q

What is validity what is perdictive validity? what is ecological validity?

A
  1. A valid test measures what it claims to measure 2. Predictive validity a) Does the measure accurately tell you about the future state of the variable being measured? 3. Ecological validity a) How well the measure reflects everyday functioning ?
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8
Q

what is reliability? what is inter-rater reliability? what is test retestreliability? what is parallel test reliability?

A
  1. A reliable test produces consistent results on each administration 2. Inter-rater reliability: do two experimenters testing the same subject get the same result? 3. Test-retest reliability: do you get the same result if you test the same subject twice? 4. Parallel test reliability: if you test the construct using different measures, are the results comparable?
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9
Q

what is sensitivity

A

a sensitive test cna identify correctly the individuals who have a disease. sensitivity = True positive/ (true positive+ false negatives)

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10
Q

what is specificity

A

a specitfic test can identify correctly the patients who do not have the disease. specificity = true negative/ (true negative +false positive)

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11
Q

what is positive predictive value

A

the ability to detect a disease given the results of the test useful for clinician depend on sensitivity, specificity, prevalence of the disease in the population positive predictive value = true positives/ (true positive +false positives)

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12
Q

Why we should not use the same diagnostic test in a hospital department and in the general population

A
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13
Q

what are the costs of a false positive

A

healthy individual, but test outcome is disease

– unnecessary worry

  • costs and side effects of unnecessary treatment
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14
Q

what are the costs of false negative diagnostic

A

individual who actually have disease, but test outcome is healthy

– failure to treat leading to symptom progression

  • social stigma or feelings of guilt
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15
Q

evaluation of genotyping

A

Advantages of genotyping

diagnostic, predictive, prenatal and even preimplantation testing

Disadvantages of genotyping

Genetic diagnostic is not a simple blood test !

Need for support and counselling, especially if no treatment exists.

Ethical implications especially for prenatal screening ie if the parent does not want to know own genetic status, parents anxious about a minor.

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16
Q

describe CT

A

computerised tomography uses X-ray beam that rotates 360 around the head,

produce images of tissue density

17
Q

evaluation of CT

A

Advantages of CT
gold standard for detecting cerebral hemorrhage in the acute phase

cheaper and more widely available

Disadvantages of CT

low spatial resolution
ionizing radiation
criterion for a lesion is not entirely objective

18
Q

describe MRI

A

magnetic resonance imaging uses magnetic fields to excite the hydrogen atoms in our bodies

these align to the magnetic field, the nreturn to equilibrium

the time to return to equilibrium varies with the type of tissue (fat, water, etc)

19
Q

MR protocols

A

T1: fast to acquire, excellent structural detail (e.g., white and grey matter), longer T1 indicates fluids and shorter T1 indicates solids

T2: slower to acquire, therefore usually better resolution than T1, good for finding lesions

emit a high density signal and appear brighter

20
Q

Evaluation of MRI

A

Advantages: safe and no ionizing radiation, excellent resolution esp on stroke sequences, esp at high magnetic field (currently 9.4T in humans

Disadvantages: lost, logistics, criterion for a lesion is not entirely objective