Lec.1 Neurotransmitters

Question 1

Neuromodulation differs than neurotransmission by …….

Answer 1

How long the substance acts on the synapse, neuromodulators have more time affecting the synapses before being inactivated

Question 2

What is myethenia gravis ?

Answer 2

Autoimmune destruction of A,Ch receptors at N.M junction

Question 3

N.Ep has 2 effects, explain?

Answer 3

Excitatory with alpha 1 receptors

Inhibitory with B2 receptors

Question 4

Effect of Dopamine??

Answer 4

Slow Inhibitory

Question 5

How cocaine is related to amphetamines ??

Answer 5

In its action.. A stimulant drugs produces euphoria by binding to the re-uptake transporters for dopamine, norepinephrine, serotonin and blocking their re-uptake into the presynaptic axon endings.

Question 6

GABA’s effect?? How?

Answer 6

Inhibitory

Through increasing conductancr of cl ions, more negativity, producing hyperpolarization of the nerve membrane.

Question 7

Glycine is …….. & Is antagonized by …….

Answer 7

Inhibitory

Strychnine

Question 8

……….. Represents 50% of catecholamines

Answer 8

Dopamine

Question 9

………….. Present 75% of excitation in CNS

Answer 9

Glutamate & Aspartate

Question 10

Benzodiazepines drugs ??

Answer 10

Increase ability of GABA
INCREASE ITS INHIBITORY EFFECT
Iv: spasms, epileptic seizures, seizures from drug overdose and poisons
Orally: anxiety, sleeplessness

Question 11

Which from slowly acting neuropeptides is:

1. Excitatory neurotransmitter of pain sensation
2. Naturally morphine like substance, modifies pain transmission

Answer 11

1. Substance p

2. Endogenous opioid peptides