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[6318] HEMATOLOGY 1 > [LEC] Overview of Hematology > Flashcards

[LEC] Overview of Hematology Flashcards

1
Q

How many ml of blood does a normal human body have?

A

5000mL or 5L

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2
Q

What are the functions of Blood?

A

â—‹ Transports oxygen from lungs to tissues
â—‹ Clears tissues of carbon dioxide
â—‹ Transports glucose, proteins, and lipids
â—‹ Moves wastes to the liver and kidneys

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3
Q

What are the three families of blood cells?

A

RBCs (Erythrocytes),
WBCs (Lymphocytes),
Platelets (Thrombocytes)

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4
Q

The study of blood cells

A

Hematology

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5
Q

Described “worms” in the blood

A

Athanasius Kircher

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6
Q

In 1674, gave an account of RBCs

A

Anton van Leeuwenhoek

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7
Q

Desribed platelets as “petites plaques”

A

Giulio Bizzozero

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8
Q

Who developed the Wright Stain?

A

James Homer Wright

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9
Q

What is a polychromatic stain?

A

A mixture of acid and basic dyes

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10
Q

The scientific term for cell appearance

A

Morphology

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11
Q

Has an a ffinity to basic structure

A

Acidic stain

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12
Q

Has an affinity to acidic structure

A

Basic Stain

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13
Q

This WBC is stained by eosin meaning its granules are ______ (basic/acidic?)

A

Eosinophil; basic

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14
Q

This WBC is stained by Methylene blue meaning its granules are ____ (basic/acidic)?

A

Basophil; acidic

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15
Q

T/F: Neutrophils are a combination of acidic and basic granules, thus they are lilac colored

A

True

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16
Q

are anucleate, biconcave, discoid cells filled with a reddish protein, hemoglobin, which transports oxygen and carbon dioxide

A

RBCs

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17
Q

RBCs appear in what color?

A

Salmon pink

18
Q

T/F: RBCs perform both aerobic and anaerobic respiration

A

False; Only anaerobic respration

19
Q

RBCs measure how much in diameter?

A

7 to 8 um

20
Q

This occupies one third of an RBC’s center, reflecting their biconcavity

A

Zone of pallor

21
Q

means loss of oxygen-carrying capacity and is often reflected in a reduced RBC count or decreased RBC hemoglobin concentration

A

Anemia

22
Q

Means an increased RBC count reflecting increased circulating RBC mass, a condition that leads to hyperviscosity

A

Polycythemia

23
Q

Polycythemia leads to

A

Hyperviscosity

24
Q

This solution matches the osmolality of blood, making the suspended RBC retain their morphology neither swelling or shrinking

A

Normal saline

25
Q

What dilution of whole blood to normal saline was typical for RBC counts?

A

1:200

26
Q

Diluted blood was transferred to a glass counting chamber called a?

A

Hematocytometer

27
Q

The first electronic counter is invented by?

A

Joseph and Wallace Coulter

28
Q

T/F: The Coulter principle of direct current electrical impedance is still used to count RBCs in many automated blood cell analyzers

A

True

29
Q

T/F: Cells are semiconductors

A

False; nonconductors, Once they pass through small apertures, if there is a blockage of current, they will be recognized as a cell.

30
Q

When a cell passes through Coulter counters it will cause a signal, this is called a/an?

A

Impedance/Pulse

31
Q

Size of RBCs

A

6-8um

32
Q

Size of Platelets

A

2-4 um

33
Q

What is the automation principle for WBCs?

A

Optical Scatter Principle

34
Q

The right angle scatter/side scatter would determine the?

A

Internal complexity of the cell/cell granularity

35
Q

The forward scatter would determine what?

A

Cell size

36
Q

Hemoglobin measurement relies on a weak solution of ______ and _____

A

Potassium cyanide and potassium ferricyanide

37
Q

a weak solution of potassium cyanide and potassium ferricyanide is called a?

A

Drabkin reagent

38
Q

What is measured through the Drabkin reagent?

A

Hemoglobin measurement

39
Q

What is the hemoglobin converted to when an aliquot of whole blood is mixed with Drabkin reagent?

A

Cyanmethemoglobin

40
Q

Also called as PCV (Packed Cell Volume)

A

Hematocrit

41
Q

In hemoglobin measurement, the absorbance or color intensity of the solution is measured in a what wavelength?

A

540 nm

[6318] HEMATOLOGY 1 (1 decks)

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