lec 7/8 clincal neuropsychology assesment (PYSC ASSESMENT) Flashcards

1
Q

case study of Mrs Y
-shows how important clincal neuropsyc is

A
  • Goldstein & McNeill, Chapter 1, p10.

-gp refused referral to clinical neurpsychologist, but social worker insisted and it still went through
-CNP needs to understand the history
* Head injury 25 years previously
-her life changed after the head injury
-Distractible during testing
WAIS FSIQ = 98. Estimated premorbid IQ = 115.
* Memory OK but learning poor
* Performance on planning and sequencing poor
* Concluded historic head injury caused lasting executive dysfunction,highly likely this caused her difficulties to cope with life/have 3 children etc

-we know now to support people with head injuries, to help executive dysfunction issues

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2
Q

use of clinical neuropsychological assesment
-main aim

A

Main aim = understand
nature of problems (related to brain illness) and how
best to support functioning
in everyday life

-to test if someone has brain illness/injury
-Case formulation: understand nature of psychological problems
-to get to the bottom of the problems

-Patient care, prognosis, planning of
interventions
-Legal assessment
-involved in Research

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3
Q

procedure of assessment for clinical neuropsychology

A
  • start by understanding Medical history , -medical assessment
  • Including neuroimaging, history, medication
  • Personal & family history, demographics (education etc)
  • Structured clinical interview (try understand from patient perspective what their problems are)
    : Assess symptoms and awareness, Assess mental state
  • Observations
  • Tests
  • Questionnaires/informant ratings etc asses mood/adaptive functioning
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4
Q

Test selection: issues to consider when choosing tests:
main aims of assessment

A

-Screening, (is there a memory problem?) diagnosis , case formulation, progress over time
* Assessment of care needs or functional potential
* Developing or measuring rehabilitation/treatment package

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5
Q

test selection: issues to consider when choosing tests

A
  • Validity and reliability of tests
    -predictive ability is often important : does the test predict whether the person will be able to function daily
    -
  • Normative data
  • Global or specific deficits?
  • Patient characteristics
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6
Q

reporting scores of neuropsyc test

A

-raw scores rarely ever used
-can compare scores to normative data

  • Standard scores: e.g. IQ (given to large sample and then normed)
  • Percentiles: percentage
    of the population who achieve less than a given score
  • IQ of 70 = 2nd percentile. (2 standard deviations below average score)
  • How decide cut-off point for ‘impairment’?
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7
Q

How decide cut-off point for ‘impairment’?

A
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8
Q

what factors need to be considered when interpreting test scores

A

Consider test scores in context of:
* Medical history, behaviour, self-reports, and personal information

  • Litigation and malingering (faking for some reason)
  • Multiple testing sessions, over time
  • Inconsistencies in performance?
  • Trajectory of scores

Concentration, motivation and emotions
- Distractibility & fatigue
- Emotions: Flat affect, anxiety, depression and frustration
all these things can impact any assesment

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9
Q

sensitivity vs specificity
-does someone have a cognitive impairment

A

sensitivity :
-the percent of diseases patients a test can capture
-all genuinely have cognitive impairment
-also known as ‘true positive impairment

specificity:
-the percent of healthy patients a test can exclude
(misdiagnosis of healthy people)
-also known as ‘true negative rate’

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10
Q

part 2
Mood disorders following brain illness- Scholten et al., (2016) systematic review

A
  • Anxiety and depression common following brain injury
  • High long term prevalence of anxiety (36%) and depression (43%).
  • Risk factors: gender (woman), unemployment, psychiatric history
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11
Q

Mood disorders following brain illness
-Other psychiatric factors (Brown, 2013)

A

Apathy, psychosis, functional neurological disorder
* May impact on all aspects of cognitive and social functioning

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12
Q

Methods of assessing mood in clinical neuropsychology

A
  • structured interviews
    -SCID = Structured Clinical Interview for DSM
    -DSM = Diagnostic and Statistical Manual of Mental
    Disorders
    -brief psychiatric rating scale

-observations
-informant reports

-self reports
* E.g. Beck Depression Inventory,
* Hospital Anxiety and Depression Scales (HADS) - a brief 14 item scale designed to give a basic assessment of anxiety - ‘often feel butterflies etc;
* Importance of insight (do they know what they have)

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13
Q

Using the HADS to assess mood following brain injury
-Whelan-Goodinson et al. (2009)

A

100 participants with traumatic brain injury
* Completed SCID and HADS
* HADS high Cronbach’s alpha (>.85)good internal reliability
* SCID and HADS convergent validity
* But 31% of participants scored in clinical range for anxiety in HADS did not meet criteria for clinical anxiety in SCID (specificity vs sensitivity problem)
-suggests HADS is not being specific enough for diagnosing anxiety (too many false positives) - cant understand if its at a clinical level

HADS = Hospital Anxiety and Depression Scales
SCID = Structured Clinical Interview for DSM

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14
Q

part 3
-assesing change in cognitive function
-why a crucial aspect

A

Crucial question in clinical assessment:
has ability/behaviour changed since
illness/injury?
What was PREMORBID ABILITY? - before ilness

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15
Q

Demographic methods to estimate premorbid ability (what function was like before ilness

A

-Use age, sex, gender, ethnic and cultural background, education and
occupation to predict premorbid IQ
* Regression methods

E.g. Crawford & Allan (1997)
* Demographic variables predict about 50% of variance in FSIQ
* Better at predicting verbal than non-verbal ability
* Poor at estimating IQs < 69, and > 120
* Occupation best predictor
16

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16
Q

specific tests pf premorbid ability
-tests that guess

A

-Hold’ tests: insensitive to brain injury
* Vocabulary tests, especially multiple choice
* Word reading tests:
* Asked to pronounce irregular words
* E.g. ACHE, IDYLL
* E.g. National Adult Reading Test (NART)
* Wechsler Test of Adult Reading (WTAR)

  • Support for construct validity:
  • Word reading fairly insensitive to
    illness/injury, and highly correlated to IQ in
    healthy sample
17
Q

Comparison of different methods of predicting IQ
Bright and van der Linde (2020)

A

Compared NART, WTAR, demographics + other methods in predicting WAIS IQ
* NART strongly predicted WAIS IQ in healthy sample (r = .69)
* WTAR similar but more limited range
* Demographic variables poorer prediction IQ
* Demographics add some incremental validity to NART prediction of IQ (add validity to nart when measuring IQ)

  • Problems with NART:
  • Regression estimates for FSIQ in manual obsolete
  • Lack of large scale norming and item analysis
18
Q

caution in interpreting reading tests as measures of premorbid ability

A
  • Evidence of validity of NART/WTAR to assess
    premorbid ability:
  • Good measure of vocabulary size
  • In healthy sample correlate highly with IQ

But reading tests are sensitive to some brain disorders:
* Moderate dementia and aphasia
-nart may not be giving an accurate measure as dementia impairs ability (memory) , same for aphasia (language problems)

May be invalid where:
* Dyslexia or pre-existing language problems
* English not 1st language
* Poor access to education

19
Q

An example of use
of the NART in a
real life situation

A

“Laced with poison:
On July 6, 1988, 20 tons of
aluminium sulphate was
accidentally dumped directly
into the household water
supply of Camelford,
Cornwall.”
-residents experienced weird taste in water, and months/years later people experienced memory and attention issues
-they were told it was just anxiety
* Mail Online 19th April 2014
20

20
Q

An example of use
of the NART in a
real life situation
-Use of the NART in Camelford poisoning case

A

Altmann et al (1999) BMJ
* Compared memory and attention of
* Camelford sample (n = 55) alleged to be poisoned
* Control group of relatives (who didnt live there or drink the poisoned water )
-
* Also gave NART to assess premorbid functioning (so any difference after the nart could be actually due to the poising)

  • Results indicated poisoning impaired cognition
  • Camelford group poorer memory and attention than relatives
  • No group difference in NART (so they must have had similar levels of cognitive functioning before the poisining)
  • This and subsequent studies led to a Government enquiry and apology in 2013
21
Q

camelford water poisoning
carole cross case

A

Carole Cross continued to drink the water after the water authority assured people that it was fit to drink. She had been a skilled craftswoman but became less able and started to have difficulty performing simple tasks such as
shopping.

  • She died in hospital in Somerset in 2004, aged 59, and was found to have a severe form of the brain disease cerebral amyloid angiopathy, (CAA) usually associated with Alzheimer’s disease. There was a “very elevated level” of
    aluminium in the brain
22
Q
A