Lec 5: Arthritides Flashcards
Most common rheumatic disease
osteoarthritis
Osteoarthritis pathogenesis
Abnormal biomechanics leading to:
sclerosis, cysts, osteophytes, inflammation
**Asymmetric distribution
OA Clinical presentation
- Gradual onset of pain
- Deep achy pain
- Pain after activity, relieved by rest
- Morning stiffness that resolves after 30min
- Damp weather?
Damp weather and OA
No link made yet, barometric pressure?
OA-Spondylosis
Degeneration of facets, discs, vertebral bodies
Degenerative Disc Disease
Back pain due to IVD degeneration
Spinal OA management
CMT PT Weight loss if indicated Exercise Traction help with stenosis
Seronegative Arthritides
Group of musculoskeletal syndromes similar to common clinical symptoms and mechanisms
*Absent rheumatoid factor
Common clinical features of Seronegative arthritides
- Male predominant
- **Spontaneous exacerbations and remission
- other issues: IBD, urethritis, eye disease
Ankylosing Spondylitis presentation
- *3mos
* *relief with mild to moderate activity
AS
**progressive spinal stiffening and fusion usually affects SIJ inflammatory arthritis Loss of lordosis, increase kyphosis Peripheral joint involvement
AS evaluation
Normal neuro/ortho exams
decrease Lumbar ROM
**Primary radiographic diagnosis
Amoss Sign
Instruct pt to get up from side lying position
Pos finding= pt places hands far from body and/or thoracic or thoracolumbar pain
AS Radiograph
- *Bilateral asymmetric widening, erosion of SIJ
- *trolley track/bamboo spine seen
- *Changes may not be visible for 4-6yrs
AS management
**Unpredictable remission/relapse
CMT to maintain mobility
Monitor for cardiac, pulmonary involvement
Reiters Syndrome/Reactive Arthritis presentation
Young male
**Urethritis, conjunctivitis, skin lesions
Reactive Arthritis
Diagnostic Triad-
- *Polyarthritis-knees, ankles, SIJ
- *Urethritis
- *Conjunctivitis
- *Lesion
Reactive Arthritis evaluation
Hx of infection present (STD)
HLA-B27 marker
**Mechanical testing of SIJ=pain
change in film unilaterally (space narrowing, erosion)
Reactive arthritis management
AB used to treat infection
CMT cautioned-could aggravate
Nonarticular symptoms resolve in days to weeks
Psoriatic Arthritis
Precedes arthritis
**Can develop n absence of detectable psoriasis
MC in whites 35-55yo
Psoriatic Arthritis with spondylitis
Occurs in 5% patients
Male predominance
**Sacroilitis if present is asymmetric
**vertebrae affected asymmetric
Red flags are
Tumor, infection, spinal fx, nuero compromise (cauda equine)
**History is everything-be specific and ask lots of questions..weight loss, fever, numbness, weakness, etc
abdominal aortic aneurysm (AAA) cause
Atherosclerosis MCC
Location of AAA
MC L2-L4
**Most asymptomatic until rupture/bleed
AAA facts
**life threatening
**MC in white males 65-75yo
M>F
AAA presentation
Mild to severe Abdominal pain or LBP
Possibly leg pain due to claudication
AAA radiograph
**>3.8cm=diagnostic
**10-20% survival rate for ruptures
>6cm needs surgical consult
Cauda Equina Syndrome presentation
LBP sciatica **bladder/bowel dysfunction **Bowel dysfunction= most sensitive/specific indicator of Cauda equine **could be fatal
Metastatic Disease
Most common site=Spine
Not relieved with bed rest
**May become symptomatic after trauma due to vertebral weakness
**Immediate referral to oncologist
Systemic Cancer
**Presents as initial spinal metastasis in 10% of pop
60-70% of systemic cancer patients will have spinal metastasis
Primary sources for metastatic disease
Lung-31%
Breast-24%
GI-9%
Multiple Myeloma
MC primary malignant tumor of bone
70% patients experience bone pain
**Lumbar spine most common site of pain
Multiple Myeloma presentation
hypercalcemia
renal disease
**Bence jones proteins found
**Osteopenia found on film
Infectious Spondylitis
**History of recent respiratory tract , urinary, skin infection
2 types of infectious spondylitis
- Pyogenic- staph (90%), strep, gram neg organsims (could involve more than one vertebra)
- Nonpyogenic- TB, fungi, brucella (centered around L1)
* *REFER OUT
Mechanical BP
Relief by rest
1 or more pain free positions
sleep possible
able to reproduce cc
Non mechanical BP
No relief of symptoms
no pain free positions
may be worse at night
unable to reproduce pain