Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Lec 2 Final > Flashcards

Lec 2 Final Flashcards

1
Q

Immune system may attack the same MO differently according to ?

A

Location

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Intracellularity does not apply to MO still within immune cell phagosomes ( T or F )

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the phagocytes that play an important role against extracellular microbes?

A

1-neutrophils
2- monocytes - macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Name 3 receptors that found on the surface of the phagocytes

A

1- Pattern recognition receptors
2- Complement receptors CR1/CR3
3- Ig receptors FcγRI and FcγRIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Phagocytosis and intracellular killing is important in facing:

A

1- Bacteria
2- Fungi (Candida spp)
3- Protozoa (Plasmodium spp, Toxoplasma spp.)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The formation of the MAC is important for killing bacteria with thin cell walls, such as Listeria monocytogenes ( T or F )

A

False, the answer is Neisseria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Who is responsible in opsonizing polysaccharide-rich encapsulated bacteria ?

A

T-independent antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name the antibodies that provide protection through steric hindrance

A

IgG, IgM, or IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Secretion of IL-1, IL-6 andIL-23 will stimulate ?

A

ILC3s and TH17 cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Secretion of IL-12 will stimulate ?

A

LC1s and TH1 cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What triggers the development of TH1 cells?

A

IL-12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the main products produced by TH1 cells?

A

IFNγ and express CD40L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the role of TH1 cells in macrophage function?

A

TH1 cells are potent activators of macrophage function, particularly for macrophages that are resistant to intracellular killing. This includes pathogens such as Mycobacterium tuberculosis, Mycobacterium leprae, and Histoplasma spp.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What can be the consequence of TH1 cell activation?

A

Activation of TH1 cells can lead to granulomatous inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the association between TH1 cells and Leishmania infection?

A

Elimination and recovery from Leishmania infection.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What cytokines do TH2 cells secrete?

A

IL-4 and IL-5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the effect of IL-4 and IL-5 secretion by TH2 cells?

A

inhibits macrophage function.

18
Q

What is the role of TH2 cells in antibody isotype switching?

A

involved in isotype switching of IgE and IgG4.

19
Q

What cytokines trigger the development of TH17 cells?

A

IL-1, IL-6, and IL-23

20
Q

What is the main cytokine secreted by TH17 cells?

A

IL-17

21
Q

What is the role of TH17 cells in immune response?

A

Recruiting neutrophils - maintenance of tight junctions

22
Q

What types of pathogens are TH17 cells important in fighting off?

A

Candida spp ( a type of fungus )

23
Q

Name the intracellular microbes

A

1- Listeria monocytogenes
2- Cryptococcus neoformans
3- Plasmodium spp
4- Toxoplasma spp

24
Q

Adaptive arm attacks the infected cells which express class I HLA molecules ( T or F )

A

True

25
Q

What are the examples of Hit and Run ?

A

common cold ,- rotavirus

26
Q

What are the examples of Silent Infection?

A

herpes simplex virus (HSV)
cytomegalovirus (CMV)

27
Q

What is the example of molecular Mimicry ?

A

Mycoplasma pneumoniae

28
Q

What are the examples of Antigenic Variation ?

A

1- HIV
2- influenza viruses
3- rhinoviruses
4- Trypanosoma brucei
5- Plasmodium spp
6- Escherichia coli
7- Neisseria gonorrhoeae

29
Q

What is the example of Antigenic Shedding ?

A

Entamoeba histolytica

30
Q

What is the example of ‘Switch-On’ of Lymphocytes ?

A

Staphylococci

31
Q

What is the example of upside-down’ direction ?

A

Some streptococci

32
Q

What are the examples of Antibody destruction ?

A

Neisseria gonorrhoeae - Haemophilus influenzae

33
Q

What is the example of TH cell destruction

A

HIV

34
Q

What are the examples of Exhaustion’ of cytotoxic T cell response ?

A

HIV - Viral hepatitis

35
Q

What is the example of Encouraging Treg cell formation ?

A

Leishmania spp

36
Q

What are the examples of Cytokine inhibition

A

Poxviruses and Epstein - Barr virus (EBV)

37
Q

Who is the father of immunology?

A

Edward Jenner

38
Q

SARS-CoV-2 vaccines produced by ?

A

1- Johnson & Johnson
2- AstraZeneca
3- Sputnik

39
Q

Vaccines against hepatitis B virus is an example of ?

A

The subunit approach

40
Q

What are the examples of Toxoid vaccines ?

A

1- pertussis (acellular)
2- Diphtheria
3- Tetanus

41
Q

BCG is an example of what type of vaccines ?

A

Live attenuated vaccine

42
Q

What are the examples of conjugate vaccines ?

A

1- Haemophilus influenzae type b
2- Pneumococci
3- Meningococci

Immunology (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions