Lec 2 Flashcards
What are the stage of healing?
Inflammation, profliferation, migration, synthesis/secretion and regeneration
What are the ‘good types’ of cellular healing, and when does the ‘bad type’ occur?
The repair and regeneration are the healthy form of cellular healing, but only,occur if the injury causing stimulus is removed. However in repair scar tissue is still formed mean the organ will not return to full function.
Fibrosis is ‘bad’ and occurs when a chronic stimulus is present. For example cirrhosis.
What cells a constant lay mitotically active?
Epithelial cells in all organs
What cells, are quiescent?
Liver, kidney and endothelium
What is scarring in terms of tissue healing?
Injured tissue is replaced by connective tissue, which could be collagen rich (temporary) or fibrotic (permanent).
What are the main cells involved in cellular healing?
Fibroblasts
Endothelial cells
Stem cells
Epithelial cells
What are the two main cell proliferation mechanisms and how do they work?
PI3K kinase pathway and MAP-kinase pathway both utilise tyrosine kinase activity, at the receptor to initiate proliferation
To get outfit G0 ____________ are used.
To promote G1 progression _____________ are used.
Cytokines
Growth factors
What cell in in the liver release cytokines to start stellar cell activation?
The livers resident kuffer cells
Name some functions of the ECM
Reservoir for growth factors
Scaffolding for cells to use.
Store Gfs and h2o
What are the three major groups of matrix component molecules?
Fibrous structural proteins, collagen and elastins
Adhesive glycoproteins, fibronectin and laminin
Gelatinous-like molecules, proteoglycans
What Marfan syndrome?
Is a connective tissue disorder.
Affect FBN1 gene that encodes for fribillin 1, which cause increase in chronic inflam, as fibrilin 1 regulates TGF - beta.
Long limb, defects in aorta and lungs
What and how do growth factors control angiogenesis?
Proliferation on the endothelium is controlled by VEGF-2 VEGFR-2
What is fibroplasia?
Is the forming of fibrous tissue, which is mass depositions of collagen are present and do not let the the tissue return to its original form
Proteoglycans do what for the ECM?
The these proteoglycans create a gel-like support of movement, in essence create a safe soft but strong area for cells. These structures can also modulate cell growth and differentiation. These proteins are also on all cell surfaces.
