Lec 17 - Viral vaccines 2 Flashcards
1
Q
adv of subunit vacc
A
- suitbale for compromised immune system
- wont trigger disease cuz no live component
- relatively stable
2
Q
disadv of subunit vacc
A
- complex to manufacture
- adjuvant and boosters needed
- takes time to determine best atnigen combo
3
Q
major viral protein on papillomavirus cell
A
L1
4
Q
what are papilloma vaccines composed of
A
hollow virus like particles assembled from recombinant HPV L1
5
Q
what is used to produce the VLPs
A
vectors that are expressed in insect cells = cloned and produces insect membranes with the L1 antigen (VLPs)
6
Q
which type of papilloma vacc is available on NHS
A
Gardasil
protects against 4 types of HPV
7
Q
A
