Lec 1

Question 1

What is the steam cell that give rise blood cell?

Answer 1

Hematopoietic steam cell

Question 2

Hematopoietic steam cell differentiate to?

Answer 2

Lymphoid steam cell & myeloid steam cell

Question 3

Myeloid stem cell give ?

Answer 3

RBCs , all leukocytes except lymphocytes,platelet by differentiated to megakaryocyte

Question 4

Lymphoid stem cell give ?

Answer 4

Lymphocytes (B & T & NK cells

Question 5

What is the typical immune response ?

Answer 5

Innate & acquired immunity

Question 6

Innate divided to ?

Answer 6

Internal & external immune response

Question 7

What is the external immune response ?

Answer 7

Skin , mucous membranes , secretion

Question 8

What is the internal innate immune response ?

Answer 8

Phagocytic cell , antimicrobial proteins , inflammatory response , NK cell (lymphocytes)

Question 9

What is the acquired immunity ?

Answer 9

This immunity is due to lymphocytes and divided to :
Humoral response which cause by antibodies (B cell)
Cell mediated response which caused by cytotoxic T cell

Question 10

Which type of leukocyte responsible in innate & acquired immunity?

Answer 10

Lymphocytes and eosinophils

Question 11

What is the hematopoiesis?

Answer 11

Blood formation

Question 12

What is the macrophages ?

Answer 12

Monocytes that migrate to tissues

Question 13

What is the count of monocytes?

Answer 13

5% of WBCs

Question 14

What is the kupffer cell?

Answer 14

Monocytes that migrate to liver OR macrophages in liver

Question 15

What is the osteoclasts, microglia , intestinal macrophages, alveolar macrophages ?

Answer 15

It is macrophages in bone , brain ,intestine and lung respectively

Question 16

What is the main function of monocytes?

Answer 16

Phagocytosis .Also , antigen presentation

Question 17

What is the big eaters cell?

Answer 17

Macrophages

Question 18

What is the most abundant WBCs?

Answer 18

Neutrophils (50-60% of WBCs)

Question 19

What is the Polymorphonuclear cell and why it called that?

Answer 19

Neutrophils because it have segmental nucleus

Question 20

How long lifespasm of RBCs?

Answer 20

120 day

Question 21

How long lifespasm of neutrophils?

Answer 21

7 houres

Question 22

What is the mature neutrophils called?

Answer 22

Segmental neutrophils

Question 23

What is the process that leukocytes invade to tissue?

Answer 23

Diapedesis

Question 24

Inflammation doesn’t affect diapedesis?

Answer 24

F , it increased it

Question 25

Which cell have powerful phagocytosis?

Answer 25

Macrophages have more powerful phagocytosis than neutrophils

Question 26

Does neutrophils have lipase to digest phagocytes ?

Answer 26

Noooo , just macrophages

Question 27

What is the process which neutrophils used to kill microbes after phagocytosis?

Answer 27

Killing by oxidizing agent

Question 28

Which WBCs increased in bacterial infection ?

Answer 28

Neutrophils because it have fastest response to bacteria

Question 29

Which WBCs increased in virus infection ?

Answer 29

Lymphocytes

Question 30

Which WBCs increased in allergy?

Answer 30

Eosinophils

Question 31

What is the substance that found in basophils granules?

Answer 31

Vasoactive amines (histamine-serotonin-heparin)

Question 32

How many loops found in neutrophils?

Answer 32

2-5 loops

Question 33

How many loops found in basophils

Answer 33

2

Question 34

What is mast cell

Answer 34

Basophils that migrate to tissue

Question 35

What is the granulocytes ?

Answer 35

WBCs that contain granules (neutrophils, basophils, eosinophils)

Question 36

Which WBCs increased in parasitic infections ?

Answer 36

Eosinophils

Question 37

What is the main function of basophils?

Answer 37

Secrete vasoactive amines

Question 38

What is the main function of eosinophils

Answer 38

Released histamine & attack parasite

Question 39

Where is B cell maturation?

Answer 39

In bone marrow

Question 40

Where is T cell maturation ?

Answer 40

I’m thymus

Question 41

Developed of lymphocytes to B or T cells depend on ?

Answer 41

Site of maturation

Question 42

Where T & B cell formed and where it maturation

Answer 42

Firstly, lymphocytes formed in bone marrow and it doesn’t known that if it T cell or B cell until it maturation , if it maturation in bone marrow , B cell will form . And if it maturation in thymus , T cell will form

Question 43

T cell divided to ?

Answer 43

T helper cell which helped B cell to produce antibodies | T cytotoxic cell which kill foreign bodies

Question 44

Which cell secret antibodies?

Answer 44

B cell

Question 45

What is the function of total count of blood cell?

Answer 45

This indicate the degree of response to infection . Differential count will provide specific diagnosis of infection , such as increase neutrophils mean bacterial infection and so on

Question 46

If one type increased , does the other type decreased ?

Answer 46

No , the proportional decreased just but the number of it will still

Question 47

What is the count of lymphocytes

Answer 47

24-40%

Question 48

What is the count of monocytes

Answer 48

5-9%

Question 49

What is the count of eosinophils

Answer 49

2-4%

Question 50

What is the count of basophils

Answer 50

0.5-1%