Learning and memory 14 Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

What is important for survival?(1)

A

The ability to associate beneficial or adverse sensory stimuli with behavioural experiences is important
for survival.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What enables an animal to elicit proactive behaviors?(1)

A

Storing and retrieving information about previous events enables an animal to elicit
proactive behaviours.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What attributes are important to an animals survival skill? What does it contribute to?(1)

A

Forming associations with positive or negative experiences, such as
remembering the location of food and water, anticipating strategies of predators based on prior
experience, and learning and respecting social relationships are important attributes to an animal’s
survival skills, and thus contribute to an individual’s fitness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is consolidation of information classified?(2)

A

Consolidation of information can be
classified into short-term and long-term memories. The resulting memories, in turn, can be
categorized as declarative or procedural.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How are different types of memories processed?(2)

A

Different types of memories are processed by different
neural circuits, and circuits that mediate memory recall are distinct from those that mediate memory
storage.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What does evidence suggest about memories?(1)

A

Evidence suggests that memories are plastic and can be modified during recall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What have studies shown about humans learning ability?(1)

A

Studies on humans have shown that learning ability, as reflected in IQ scores, is highly
heritable.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Do different memories have the same function? (1)

Give examples of short term and long term memory?(2)

A

Short-term memories and long-term memories serve different functions. (Example of parking at the
mall-> short term; designated parking spot on campus / way from home to campus ->long term).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does one invariably find when comparing different learning paradigms for the formation of long term memories?(2)

a. What does this tell us about how students should study?(1)
b. What does the spaced learning pattern ensure?(1)
c. Advantage and disadvantage of masses learning?(2)

A

When different learning paradigms for the formation of long-term memories are compared in a variety
of model organisms, one invariably finds that repeated training sessions separated by time intervals
(spaced learning) are far more effective for the consolidation of long-term memory than a single
continuous intensive training session (masses training).

a.Student should study repetitively over a
period of time (spaced learning) rather than doing the cramming session (masses training) the night
before the exam.

b.The spaced learning pattern will ensure that the information is processes and stored
as long-term memory.

c.Even though the masses training will retain the information in the short-term
memory, and help the student to pass the exam the next morning, over time, this information will be
forgotten

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How is long-term memory classified as?(2) define each(2)

A

Long-term memory can be classified as:
- Declarative memory: storage of factual information
- Procedural memory: execution of skills that cannot be readily verbalized (learning to swim /
play piano).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How is declarative memory classified?(2) Give a description aswell as an example.(2)(2)

A

o Semantic memory: conceptual knowledge that is independent of specific facts
(vegetables are good for you; carrots gives you good eyesight, pumpkin gives you curly
hair).

o Episodic memory: recollection of specific events, times, and places  not static and
can be modified and reconsolidated on recall.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What have studies on the cellular and neural mechanisms that mediate learning and memory made use of?(1)

A

Studies on the cellular and neural mechanisms that mediate learning and memory have made
extensive use of behavioural assays that are based on associative learning or operant conditioning.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

a. When are short-term memories formed?(1)
b. When does consolidation of long-term memories take place?(1)
c. What does the formation of long-term memories require?

A

a.Short-term memories are formed as training proceeds.

b.Consolidation of long-term memories takes
place subsequent to the training session.

c.The formation of long-term memories requires protein
synthesis, which depends on gene expression, which ultimately leads to long-lasting structural
changes in neuronal connections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Several independent mutant screens (on flies) have identified a diverse array of genes that affect
learning and memory.

These genes generally fall into which two categories?

A
  • Genes that prevent short-term memory formation

- Genes that affect the retention of information in long-term memory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The genetics of dyslexia:

a. How did speech evolve?(1)
b. What about writing and reading?(1)
c. What is acquiring reading skills to understand written language?(1)
d. How have genetic studies on dyslexia been informative?

A

a.Speech evolved as an intrinsic behavioural trait during human evolution,

b.but writing and reading are
cultural innovations that appeared in human history only a few thousand year ago.

c.Acquiring reading skills to understand written language is purely a learned behaviour.

d. Genetic studies on dyslexia have
been informative in identifying alleles that impact the ability to learn written language.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The genetics of dyslexia

a. What do individuals with dyslexia suffer from? phenotype
b. How does dyslexia differ from genetic defects that cause mental retardation?(1)

A

a.Individuals with dyslexia find it difficult to acquire and consolidate written information. Phonological
deficiencies (inability to process speech sounds and recognition of words and their meaning) are also
common.

b.However, in contrast to learning disabilities that result from genetic defects that cause
mental retardation, such as Down syndrome, people with dyslexia show normal performance with
regard to other cognitive functions, and have normal or higher than normal intelligence.

17
Q

The genetics of dyslexia

a. How common is this learning disability?(1)
b. What has heritability of dyslexia been estimated at?(1)
c. What have there studies used?(4)
d. What is transmission disequilibrium?(1)

A

a. This learning disability is extremely common.
b. Heritability of dyslexia has been estimate at about 40% to 70% - where genetic variation contributes prominently to this learning disability.

c.These studies have used either comparisons between MZ twin and DZ twins, linkage studies based on transmission
of the disorder in families, and association studies in populations.

d.The non-random association
between an allele and a phenotype in family studies is known as transmission disequilibrium.

18
Q

The genetics of dyslexia

a. What have combination of studies resulted in?
b. What are the most notorious amongst these candidate genes?

A

a.Combinations of such studies have resulted in the identification of several chromosomal regions that
contain candidate genes which harbour polymorphisms that may contribute to the susceptibility for dyslexia.

b.The most notorious among these candidate genes are DYX1C1, KIAA00319, DCDC2, ROBO1

19
Q

The genetics of dyslexia

a. where were they identified?(2)
b. Discuss all of these 4 genes extensively.

A

a.They were identified in independent genetic studies, but are functionally-related.

b. 1. DYX1C1
Dyslexia-susceptibility-1, candidate-1.The result of a rare chromosomal translocation, involving chromosomes 2 and 15. There are
also 2 rare SNPs found in higher frequency in individuals suffering from dyslexia. This was all
found in a Finnish population, derived from a small founder population, making them
genetically more homogeneous than other population, explaining why this couldn’t be
replicated in other populations.

  1. KIAA0319
    On chromosome 6. This was found in 2 populations: a British population (Berkshire), and an
    American population (Colorado). The complication around this gene is its connection to
    another gene (adjacent to it), also connected to dyslexia – the DCDC2 gene.
  2. DCDC2
    Associated with brain disorders resulting from deficits in neuronal tandem repeat sequences
    in an intron. Associations were found between the short tandem repeats and dyslexia. It was
    later proven in a linkage study in a German population to be a candidate gene.
  3. ROBO1
    The discovery of this candidate gene came from 2 interesting cases:
    - A large Finnish family, consisting of 4 generations and 74 members, of which 27 were
    dyslexic, showed a simple single dominant gene linked to a region on chromosome 3.
    - Another translocation was implicated between chromosome 3 and chromosome 8. This
    translocation pinned the phenotype down to a disruption in ROBO1. It appears that the
    reduction in expression of this gene during development of the nervous system
    predisposes to dyslexia.
20
Q

Despite the controversial results in all of the experiments related to these genes and dyslexia, the fact
that all of them relate to cell migration, cell adhesion and axon growth, which can explain some of the
cortical malformations seen in some cases of dyslexia, establishes them as interesting candidate
genes. Which questions are raised?

A

Which sequence variants are associated with dyslexia?

How predictive are these alleles for the manifestation of this disorder?

Why should genes that are expressed widely throughout the developing brain selectively affect a
particular cognitive function mediated by distinct cortical regions that are associated with speech and
audition?

Do these genes only function during development, or do they also have functions in specific cortical
regions in the adult brain?

What other genes interact with these four candidate genes to enable writing and reading ability?

21
Q

a. What made our ability to communicate through writing possible?(1)
b. Why are these genes necessary?(1)

A

a.Our ability to communicate through writing did not require the evolution of new genes, but was made possible through the recruitment of existing genetic networks of pleiotropic genes.

b.These genes are necessary for the formation of neural circuits that happen to be suitable of
the performance of this cognitive task.