Laxatives Flashcards
1
Q
What type of laxative is senna and where does it act
A
- stimulant
- peristalsis
2
Q
What type of laxative is lactulose and where does it act
A
- osmotic
- water colon
3
Q
What type of laxative is ispaghula husk
A
- bulk-forming
- fibre drawing water
4
Q
Contraindications for laxatives
A
- intestinal obstruction
- IBD
- paralytic ileus
- toxic megacolon
- atomic colon
5
Q
Excretion of laxatives
A
Faeces
6
Q
Which laxative can increase digoxin toxicity
A
Senna
7
Q
If taken without enough liquid, which laxative can form dry and hard stool
A
Ispaghula husk
8
Q
Common use of laxatives
A
Counter constipation caused by opioids
9
Q
Look out for …. when taking laxatives, especially in kidney px
A
Dehydration
10
Q
detailed mechanism of lactulose
A
o Laxative – synthetic disaccharide
o Colon breakdown by bacteria –> fatty acids
o Lower colonic pH: NH4 formed over NH3 – NH4 not absorbed
o – plasma NH3
