Lange Q&A book Flashcards
A 53 y/o obese man presents with a third attack of gout within 1 year. Following the tx of this acute attack, further lab testing is performed and the pt is found to have an elevated serum uric acid level and a 24hr uric acid secretion of 950mg. Which of the following meds would be most appropriate to initiate for prevention of further gouty attacks?
a: colchicine
b: probenecid
c: prednisone
d: allopurinol
e: indomethacin
d: medications used to prevent gout exacerbation include allopurinol and uricosuric drugs, s/a probenecid. Allopurinol inhibits the production of uric acid and is indicated for patients who overproduce uric acid, and uricosuric drugs are used in pts who undersecrete uric acid. Criterion to classify a pt as an overproducer of uric acid is a 24hr uric acid excretion test. The result showing uric acid excretion of 800mg or greater indicates that the pt is an overproducer. In this pt scenario, there is an overproduction of uric acid, making the case for the use of allopurinol. If this pts 24hr uric acid secretion was less than 800mg, the use of a uricosuric drug would then be appropriate. Prednisone, colchicine, and indomethacin are alternative txs for acute attacks of gout and are not used for preventive measures.
A 32 y/o woman with hx of anxiety presents with worsening fatigue and sleep disturbance associated with unbearable “pain all over the body” for the past several months. The PE is essentially unremarkable except for localized painful tenderness to palpation over the trapezius, upper back, and buttocks. Which of the following is the most likely dx?
a: fibromyalgia
b: polymyositis
c: Paget disease
d: polymyalgia rheumatica
e: SLE
a: fibromyalgia. It is most frequently seen in women between ages 20-50. Pts complain of chronic msk pain commonly associated with fatigue and sleep disturbances as well as HA and numbness. PE is normal except for the presence of multiple “trigger points.”
The dx of SLE is supported by a positive initial antibody screen; however, this test is not specific. Which of the following tests is most specific in the diagnostic evaluation of SLE?
a: gliadin antibody
b: antibody to double-stranded DNA (anti-dsDNA)
c: antinuclear antibody (ANA)
d: anticentromere antibody
e: antiribosomal P antibody
b: autoantibody production is the primary immunological abnormality seen in pts with SLE; the ANA is most characteristic of SLE and seen in 95% of pts with SLE but is not specific for dx of SLE. A positive ANA can also be found in pts with scleroderma, rheumatoid arthritis, Sjogren’s, dermatomyositis, and polyarteritis. ANA testing should be employed as the initial screening test in a pt suspected of having SLE. A negative total ANA test is strong evidence against the dx of SLE, whereas a positive test is not confirmatory of the dx.
Skin thickening that begins as swelling of the fingers and hands associated with telangiectasia, dysphagia, and hypomotility of the GI tract is most likely seen with which of the following?
a: sarcoidosis
b: scleroderma
c: dermatomyositis
d: eosinophilic fasciitis
e: eosinophilia-myalgia syndrome
b: scleroderma is characterized by diffuse thickening of the skin and is associated with areas of telangiectasia and changes in skin pigmentation. Most pts with scleroderma also have an associated polyarthralgia, Raynaud phenomena, and GI involvement.
Which of the following conditions is strongly associated with systemic scleroderma (SS)?
a: polymyositis
b: reactive arthritis
c: dermatomyositis
d: Sjogren disease
e: Raynaud phenomenon
e: Most pts with SS will also have vascular dysfunction, most commonly Raynaud phenomenon. There is no increased association of scleroderma with polymyositis, reactive arthritis, dermatomyositis, or Sjogren ds.
A 65 y/o man presents with complaints of acute onset of pain/swelling of the R. great toe. He denies any recent alcohol ingestion or trauma to the area. On PE, the pt is afebrile, and the first metatarsophalangeal joint is erythematous, swollen, and warm to the touch. Lab evaluation reveals a WBC count of 12,000 and a normal differential. Serum uric acid level is found to be 5 mg/dL. Synovial fluid analysis reveals the presence of rhomboid-shaped crystals. Which of the following is the most likely dx?
a: acute gout
b: pseudogout
c: psoriatic arthritis
d: infectious arthritis
e: rheumatoid arthritis
b: Pseudogout presents similarly to acute gout and is best dx by finding of the rhomboid-shaped crystals of calcium pyrophosphate in joint aspirates. Joints commonly involved in pseudogout are the knees and wrists and other joints such as the metacarpophalangeals, hips, shoulders, ankles, and elbows. The dx of pseudogout is further supported by the finding of a normal serum uric acid level. Acute gout would more likely be associated with an elevated serum uric acid level. Psoriatic arthritis commonly presents with asymmetrical oligoarticular involvement of two to four joints, and in a higher % of pts, there is known presence of the dermatological expression of psoriasis. In infectious (septic) arthritis, the WBC count would be between 50,000-200,000. Rheumatoid arthritis usually presents with symmetrical polyarticular involvement of 3 or more joints.
Which of the following patterns of stiffness is most characteristic of pts with rheumatoid arthritis?
a: morning stiffness lasting at least 1 hour
b: exacerbation of joint stiffness with walking
c: frequent, brief episodes of stiffness after inactivity
d: stiffness reflected by a major delay in muscle relaxation
e: stiffness evidenced by increased resistance to passive movement
a: morning stiffness lasting at least 1 hour is characteristic of rheumatoid arthritis (RA). Exacerbation of joint stiffness with weight bearing (s/a walking) and frequent, brief episodes of stiffness (lasting
Related infections that have been identified as triggers of reactive arthritis include sexually transmitted infections and which of the following other types of infections?
a: ear infections
b: eye infections
c: enteric infections
d: musculoskeletal infections
e: CNS infections
c: Reactive arthritis, previously known as Reiter syndrome, typically presents with the clinical triad of urethritis, conjunctivitis, and arthritis. Most cases of reactive arthritis are associated with either a sexually transmitted infection or an enteric infection. Common STI etiological triggers are Chlamydia trachomatis or Ureaplasma urealyticum. Enterically Shigella, Salmonella, Yersinia, or Campylobacter are organisms associated with reactive arthritis.
A 45 y/o woman with recent dx of rheumatoid arthritis (RA) has begun tx with celecoxib. She has been on this medication for 3 months and notes that her pain continues. Early signs of joint involvement are present in the patient’s hands. Which of the following medications is the most appropriate to add to her tx?
a: aspirin
b: rituximab
c: etanercept
d: leflunomide
e: methotrexate
e: The tx of RA is aimed at reduction of pain, preservation of function, and prevention of deformity. Although NSAIDs provide symptomatic relief, they do not alter progression or prevent erosion of the joint. In addition to NSAID therapy, DMARDs should also be initiated as soon as the dx is confirmed. The most common initial DMARD used as tx of RA is methotrexate. Aspirin should not be added because of the increased risk of GI side effects as well as having no effect on altering RA disease progression. Rituximab is a bDMARD and is indicated to be added in pts with RA refractive to tx with combination therapy of methotrexate and a TNF inhibitor. Etanercept is a TNF inhibitor. This class of meds is often added in pts with PA who are not responding to methotrexate alone. Leflunomid is a pyrimidine synthesis inhibitor that is approved for the tx of RA; however, it is contraindicated for use in premenopausal women secondary to its carcinogenic and teratogenic potential
A 48 y/o woman presents with a cc of gradually progressing difficulty in climbing the stairs over the past 3 months. The PE shows there is notable proximal muscle weakness of the upper and lower extremities. The remainder of the examination is unremarkable. The lab evaluation shows an elevated serum creatinine phosphokinase level, and a muscle bx reveals lymphoid inflammatory infiltrates. Which of the following is the appropriate initial tx of choice for this pt?
a: prednisone
b: azathioprine
c: methotrexate
d: immunoglobulin
e: hydrochloroquine
a: The most likely dx is this patient is polymyositis. This is supported by the finding of gradual progressive proximal muscle weakness and elevation of creatinine phosphokinase level. The finding of the lymphoid inflammatory infiltrates on muscle bx confirms the dx. Initial tx of choice in this condition is the use of a corticosteroid (prednisone). Pts who do not respond to prednisone may then benefit from use of methotrexate or azathioprine. Both IV immune globulin and hydroxychloroquine are effective for the tx of pts with dermatomyositis that is resistant to prednisone therapy.
Which of the following is the correct term to describe the abrupt onset of swelling and extreme tenderness to palpation involving the metatarsophalangeal joint of the great toe?
a: crepitus
b: podagra
c: xerostima
d: trigger point
e: chondrocalcinosis
b: Podagra is the term utilized to denote the involvement of the great toe in cases of gout. Crepitus refers to sound or feeling associated with movement of joints due to joint irregularities. Xerostima is the term applied to symptoms of dryness of the mouth, which may be seen in Sjogren’s. Trigger points typically describe areas of pain revealed by palpation of involved muscle areas in pts with fibromyalgia. Chondrocalcinosis refers to presence of calcium-containing salts in articular cartilage associated with metabolic diseases, s/a pseudogout.
Which of the following is an established risk factor for osteoporosis and is also an indication for measuring bone density?
a: obesity
b: alcoholism
c: hypercalcemia
d: history of scoliosis
e: short-term corticosteroid therapy
b: Risk factors for osteoporosis and indications for measuring bone density include alcoholism. Low BMI (6mg or prednisone for more than 1month), not short term corticosteroid therapy are also indications for measuring bone density.
A 22 y/o man presents with an insidious onset of low back pain over the last 6 months. He describes the pain as dull and has difficulty localizing the pain. The pain radiates to his thighs. The pain is worse in the morning and associated with stiffening that lessens during the day. The pt notes that there is no hx of trauma. The initial lab evaluation shows an elevated EST, positive HLA-B27, and a negative RF. Plain films of the lumbar spine reveal bilateral blurring of the sacroiliac joints. Which of the following is the most likely dx?
a: SLE
b: lumbar disc disease
c: RA
d: anklyosing spondylitis
e: polymyalgia rheumatica
d: Ankylosing spondylosis is the most likely dx in this pt. This condition is a chronic inflammatory disorder of the joints of the axial skeleton and commonly presents in the late teens or twenties. Male pts have a higher incidence than do female pts. A common presentation is pain in the lower back with radiation to the thighs and associated limitation of movement that may lessen during the day. Lab findings include elevated ESR and a positive HLA-B27. The HLA-B27 is not a specific test for ankylosing spondylitis; a small % of the normal population has a positive finding of this antigen. The earliest radiographic findings occur in the sacroiliac joints, with detection of erosion and blurring of the joint space “bamboo spine”
Which of the following clinical manifestations is associated with systemic disorders that are HLA-B27 related, including anklyosing spondylitis, reactive arthritis, psoriasis, and Behcet syndrome?
a: uveitis
b: dysentary
c: vasculitis
d: hyperuricemia
e: thoracic involvement
a: Uveitis is an associated finding. These disorders can cause a nongranulomatous anterior uveitis that usually presents unilaterally with pain, redness, photophobia, and visual loss. Dysentary is more likely to be associated with reactive arthritis. Vasculitis is seen with Behcet disease. Hyperuricemia may be found with psoriasis. Thoracic involvement is often found in ankylosing spondylitis.
A 67 year old man presents with pain and stiffness in his shoulders and hips lasting for several weeks with no hx of trauma. He also has complaints of HA, throat pain, and jaw claudication. It is imperative to dx this pt promptly in order to prevent which of the following conditions?
a: anemia
b: cerebral aneurysms
c: mononeuritis multiplex
d: ischemic optic neuropathy
e: respiratory tract complicatoins
d: The most urgent need for dx of a pt with symptoms of polymyalgia rheumatica (PMR) and giant cell arteritis is to prevent blindness caused by ischemic optic neuropathy as a result of occlusive arteritis of the ophthalmic artery. Early dx is imperative as the neurological damage to the optic nerve is not reversible.