Labour and Delivery - done Flashcards
When do labour and delivery normally occur?
Between 37 and 42 weeks gestation
What are the three stages of labour?
First stage - from onset until 10cm cervical dilation
Second stage - from 10cm cervical dilation until delivery of baby
Third stage - from delivery of baby to delivery of placenta
What changes to the cervix happen in the first stage of labour?
Cervical dilation - opening up
Effacement - getting thinner
What is the “show” in a pregnant womans cervix?
Mucus plug = prevents bacteria from entering during the pregnancy
What are the 3 phases to the first phase of delivery?
Latent phase = from 0 to 3cm - progresses at 0.5cm per hour - irregular contractions
Active phase = from 3 to 7cm - progresses at 1cm per hour - regular contractions
Transition phase = from 7 to 10cm - progresses at 1cm per hour - strong and regular contractions
What are Braxton-Hicks contractions?
Occasional irregular contractions of the uterus (felt during 2nd and 3rd trimester)
Not indicating the onset of labour - staying hydrated and relaxing reduces these contractions.
What are the signs of labour?
Show (mucus plug from the cervix)
Rupture of membranes
Regular, painful contractions
Dilating cervix on examination
What are the latent first stage of labour and the established first stage of labour?
Latent first stage = painful contractions, changes to the cervix, with effacement and dilatation up to 4cm
Established first stage = regular, painful contractions, dilatation of the cervix from 4cm onwards
What does ROM stand for?
Rupture of membranes
What does SROM stand for?
Spontaneous rupture of membranes
What does PROM stand for?
Prelabour rupture of membranes (amniotic sac has ruptured before the onset of labour)
What does P-PROM stand for?
Preterm prelabour rupture of membranes (P-ROM) - the amniotic sac has ruptured before the onset of labour and before 37 weeks gestation (preterm)
What does PROM stand for?
Prolonged rupture of membranes (also PROM) - The amniotic sac ruptures more than 18 hours before delivery
What is prematurity?
Birth before 37 weeks gestation
When are babies considered non-viable?
Before 23 weeks gestation
What chance of survival do babies born at 23 weeks have?
10% chance of survival
What gestational age will a full resuscitation be offered from?
24 weeks
What is the WHO classification of prematurity?
Under 28 weeks: extreme preterm
28 – 32 weeks: very preterm
32 – 37 weeks: moderate to late preterm
What are the 2 options for prophylaxis of pre-term labour?
Vaginal progesterone
Cervical cerclage
How does vaginal progesterone protect against pre-term labour?
Given as a gel or pessary
Decreases activity of the myometrium and prevents the cervix from remodelling in prep for delivery
Who is vaginal progesterone offered to?
Women with a cervical length less than 25mm on vaginal ultrasound between 16 and 24 weeks gestation
How does cervical cerclage work?
Putting a stitch into the cervix to add support and keep it closed, involves a spinal or general anaesthetic
When is a cervical cerclage reversed?
When the woman goes into labour or reaches term
Who is offered cervical cerclage?
Women with a cervical length less than 25mm on vaginal ultrasound between 16 and 24 weeks
Previous premature birth or cervical trauma (e.g. colposcopy and cone biopsy)
When is a rescue cervical cerclage offered?
Between 16 and 27+6 weeks when there is cervical dilatation without rupture of membranes to prevent progression and premature delivery
What is preterm prelabour rupture of membranes?
Where the amniotic sac ruptures before the onset of labour and in a preterm pregnancy (under 37 weeks gestation)
How is P-PROM diagnosed?
Speculum examination revealing pooling of amniotic fluid in the vagina - no tests are required
What tests can be used to confirm the diagnosis of P-PROM?
- Insulin-like growth factor-binding protein-1 (IGFBP-1)
- Placental alpha-microglobin-1 (PAMG-1)
What is IGFBP-1?
A protein present in high concentrations in amniotic fluid which can be tested on vaginal fluid if there is doubt about rupture of membrane
What is PAMG-1?
Similar alternative to IGFBP-1
What is the management of P-PROM?
Prophylactic antibiotics given to prevent chorioamnionitis
What antibiotics are recommended to prevent chorioamnionitis?
Erythromycin 250mg 4 times daily for 10 days or until labour is established if within 10 days
When is induction of labour offered for P-PROM patients?
From 34 weeks
What is preterm labour with intact membranes?
Preterm labour with intact membranes with regular painful contraction and cervical dilatation, without rupture of the amniotic sac
How is preterm labour with intact membranes diagnosed?
Clinical assessment with speculum examination to assess for cervical dilatation
How is preterm labout with intact membranes diagnosed less than 30 weeks gestation and more than 30 weeks gestation?
Less than 30 weeks gestation = Clinical assessment alone
More than 30 weeks gestation = Transvaginal ultrasound can be used to assess the cervical length (if less than 15mm management of preterm labour can be offered - if more than 15mm then preterm labout is unlikely)
What is an alternative test for preterm labour without membrane rupture?
Fetal fibronectin (the “glue” between the chorion and the uterus and is found in the vagina during labour)
Result of less than 50ng/ml is considered negative and indicates that a preterm labour is unlikely
What is included in the management of preterm labour?
Fetal monitoring (CTG or intermittent auscultation)
Tocolysis with nifedipine: nifedipine is a calcium channel blocker that suppresses labour
Maternal corticosteroids: can be offered before 35 weeks gestation to reduce neonatal morbidity and mortality
IV magnesium sulphate: can be given before 34 weeks gestation and helps protect the baby’s brain
Delayed cord clamping or cord milking: can increase the circulating blood volume and haemoglobin in the baby at birth
What is tocolysis?
Medication to stop uterine contractions - nifedipine, a CCB, is the medication of choice for tocolysis
What is an alternative to nidefipine for tocolysis?
Atosiban, an oxytocin receptor antagonist
When can tocolysis be used?
Between 24 and 33 + 6 weeks gestation in preterm labour to delay delivery and buy time for further fetal development, administration of maternal steroids or transfer to a more specialist unit (e.g. with a neonatal ICU)
ONLY USED AS A SHORT TERM MEASURE - less than 48 hours
Why are antenatal steroids given?
Develop the fetal lungs and reduce respiratory destress syndrome after delivery
Used in women with suspected preterm labour of babies less than 36 weeks gestation
What is an example regimine of antenatal steroids?
Two doses of intramuscular betamethasone, 24 hours apart
What is IV magnesium sulphate given for?
Protect the fetal brain during premature delivery. Reduces the risk and severity of cerebral palsy.
When is IV magnesium sulphate given?
Within 24 hours of delivery of preterm babies of less than 34 weeks gestation
Given as a bolus followed by an infusion for up to 24 hours of up until birth
What do mothers that are given IV magnesium sulphate need monitoring for?
Magnesium toxicity at least four hourly
Monitor tendon reflexes (usually patella reflex)
- Reduced resp rate
- Reduced blood pressure
- Absent reflexes
What is induction of labour?
Use of medication to stimulate the onset of labour
When is induction of labour offered?
Between 41 and 42 weeks gestation
When is induction of labour offered?
- Preterm rupture of membranes
- Fetal growth restriction
- Pre-eclampsia
- Obstetric cholestasis
- Existing diabetes
- Intrauterine fetal death
What is the Bishop Score?
Scoring system used to determine whether to induce labour
What is assessed in the Bishop’s criteria and what is the maximum score?
Fetal station (scored 0 – 3)
Cervical position (scored 0 – 2)
Cervical dilatation (scored 0 – 3)
Cervical effacement (scored 0 – 3)
Cervical consistency (scored 0 – 2)
What Bishop score predicts a successful induction of labour?
8 or more (a score below this suggests cervical ripening may be required to prepare the cervix)
What are the options for induction of labour?
Membrane sweep
Vaginal prostaglandins E2 (dinoprostone)
Cervical ripening ballon (CRB)
Artifical rupture of membranes
Oral mifepristone (anti-progesterone) plus misoprostol
What is a membrane sweep?
Inserting a finger into the cervix to stimlate the cervix and begin labour.
Can be performed in antenatal clinic and if successful should produce the onset of labour within 48 hours
Seen as an assistance fore the full induction of labour.
Used from 40 weeks gestation to attempt to initiate labour in women over their EDD
What does a vaginal prostaglandin E2 (dinoprostone) involve?
Inserting a gel, tablet (Prostin) or pessary (propess) into the vagina.
The pessary is similar to a tampon, slowly releasing local prostaglandins over 24 hours.
Stimulates uterus and causes the onset of labour.
Usually done in the hospital setting so the woman can be monitored before being allowed home to await the full onset of labour.
What is a cervical ripening ballon?
Silicone ballow which is inserted into the cervix and gently inflated to dilate the cervix
Used ias an alternative where vaginal prostaglandins are not preferred, usually in women with a previous C-section or where vaginal prostaglandins have failed or multiparous women (para 3)
What is the artificial rupture of membranes?
With an oxytocin infusion can also be used to induce labour.
This is used there there are reasons not to use vaginal prostaglandins, can be used also to progress the induction of labour after vaginal prostaglandins have been used
When are oral mifepirstone (anti-progesterone) plus misoprostol used?
To induce labour where intrauterine fetal death has occured
What are the two means for monitoring during the induction of labour?
Cartiotocography (CTG) to assess the fetal heart rate and uterine contractions before the induction of labour
Bishop score before and during the induction of labour to monitor the progress
What is the ongoing management of IOL?
Most women will give birth within 24 hours of the start of induction of labour
The options where there is slow or no progress include:
- Further vaginal prostaglandins
- Artificial rupture of membranes and oxytocin infusion
- CRB
- Elective caesarean section
What is the main complication of using vaginal prostaglandins to induce labour?
Uterine hyperstimulation - causing fetal distress and compromise
What is the criteria for uterine hyperstimuation?
Varies between guidelines, two criteria often used are:
- Individual uterine contractions lasting more than 2 minutes in duration
- More than 5 uterine contractions every 10 minutes
What adverse outcomes can uterine hyperstimuation lead to?
- Fetal compromise, with hypoxia and acidosis
- Emergency C-section
- Uterine rupture
What is the management of uterine hyperstimuation?
- Removing the vaginal prostaglandins, stopping the oxytocin infusion
- Tocolysis with terbutaline
What does cartiotocography do?
Measures the fetal heart rate and the contractions of the uterus
What is cartiotocography also known as?
Electronic fetal monitoring
Where are the transducers for CTG placed?
One above the fetal heart to monitor the fetal heartbeat
One near the fundus of the uterus to monitor the uterine contractions
How does the transducer above the fetal heart monitor the heartbeat?
Using doppler ultrasound
How does the transducer above the fundus measure uterine contraction?
Using ultrasound to assess tension
What are the indications for using continuous CTG measuring in labour?
Sepsis
Maternal tachycardia (> 120)
Significant meconium
Pre-eclampsia (particularly blood pressure > 160 / 110)
Fresh antepartum haemorrhage
Delay in labour
Use of oxytocin
Disproportionate maternal pain
What are the five key features to look for on a CTG?
Contractions – the number of uterine contractions per 10 minutes
Baseline rate – the baseline fetal heart rate
Variability – how the fetal heart rate varies up and down around the baseline
Accelerations – periods where the fetal heart rate spikes
Decelerations – periods where the fetal heart rate drops
What do number of contractions indicate?
The activity of labour
What do too few or too many uterine contractions indicate in labour?
Too few = labour isnt progressing
Too many = uterine hyperstimuation
What are accelerations a sign of?
Good sign that the fetus is healthy particularly when occuring alongside contractions of the uterus
What are the different categories for baseline rate on an CTG?
Reassuring
Non-reassuring
Abnormal
What baseline rate and varability on a CTG is reassuring?
Baseline rate = 110-160
Variability = 5-25
What baseline rate and variability is non-reassuring?
Baseline rate = 100-109 or 161-180
Variability = less than 5 for 30-50 mins or more than 25 for 15-25 mins
What CTG baseline rate and variability is considered abnormal?
Baseline rate = Below 100 or above 180
Variability = Less than 5 for over 50 mins or more than 25 for over 25 mins
What are decelerations?
Concerning finding, fetal heart rate drops in response to hypoxia (fetal heart rate is slowing to conserve oxygen for the vital organs)
What are the four types of decelerations?
Early decelerations
Late decelerations
Variable decelerations
Prolonged decelerations
What are early decelerations?
Gradual dips and recoveries in HR that correspond with uterine contractions
What are early decelerations?
Gradual dips and recoveries in HR which correspond with uterine contrations (lowest point of deceleration corresponds to the peak of the contraction)
What causes early decelerations, are they a worry?
Caused by the uterus compressing the head of the fetus, stimulating the vagus nerve of the fetus, slowing the HR.
Normal and not considered pathological
What are late decelerations?
Gradual falls in HR, which start after the uterine contraction has already begun - delay between uterine contraction and deceleration - lowest point of the deceleration occurs after the peak of the contraction
What causes late decelerations?
Caused by hypoxia in the fetus and are a more concerning finding, may be caused by excessive uterine contractions, maternal hypotension/hypoxia
What are variable decelerations?
- Abrupt decelerations which may be unrelated to uterine contractions, fall of more than 15bpm from the baseline
- Lowest point occurs within 30 seconds and the deceleration lasts less than 2 minutes in total
What do variable decelerations indicate?
Intermitten compression of the umbilical cord causing fetal hypoxia
What is a reassuring sign of variable decelerations?
Brief accelerations before and after the deceleration, known as shoulders (reassuring sign that the fetus is coping)
What is a prolonged deceleration?
A deceleration which lasts more than 15 bpm from baseline - often indicating compression of the umbilical cord causing fetal hypoxia. These are abnormal and concerning
When is the CTG reassuring?
No decelerations
Early decelerations
Less than 90 mins of variable decelerations with no concerning features
What CTG findings are classed as non-reassuring?
Regular variable decelerations
Late decelerations
What CTG findings are always abnormal?
Prolonged decelerations
What categoried are the CTGs interpreted upon?
- Baseline rate
- Variability
- Decelerations
What are the four categoties for CTF?
Normal
Suspicious: a single non-reassuring feature
Pathological: two non-reassuring features or a single abnormal feature
Need for urgent intervention: acute bradycardia or prolonged deceleration of more than 3 minutes
What management options are there for a concerning CTG?
Escalating to a senior midwife and obstetrician
Further assessment for possible causes, such as uterine hyperstimulation, maternal hypotension and cord prolapse
Conservative interventions such as repositioning the mother or giving IV fluids for hypotension
Fetal scalp stimulation (an acceleration in response to stimulation is a reassuring sign)
Fetal scalp blood sampling to test for fetal acidosis
Delivery of the baby (e.g. instrumental delivery or emergency caesarean section)
What is the rule of 3s for fetal bradycardia?
3 minutes – call for help
6 minutes – move to theatre
9 minutes – prepare for delivery
12 minutes – deliver the baby (by 15 minutes)
What is a sinusoidal CTG?
Rare pattern to be aware of as it can indicate severe fetal compromise
Pattern similar to a sine wave with smooth regular waves up and down which have an amplitude of 5-15bpm
Usually associated with severe fetal anaemia e.g. caused by vasa praevia with fetal haemorrhage
What is the mneumonic for assessing a CTG in a structured way?
DR C BRaVADO
DR – Define Risk (define the risk based on the individual woman and pregnancy before assessing the CTG)
C – Contractions
BRa – Baseline Rate
V – Variability
A – Accelerations
D – Decelerations
O – Overall impression (given an overall impression of the CTG and clinical picture)
How can the overall impression of a CTG be given?
Normal (all features are reassuring)
Suspicious
Pathological
Need for urgent intervention
What are the medications commonly used during labour?
Oxytocin
Ergometrine
Prostaglandins
Misoprostol
Mifepristone
Nifedipine
Terbutaline
Carboprost
Tranexamic acid
What is oxytocin?
Hormone secreted by the posterior pituitary gland (produced in the hypothalamus)
What is the role of oxytocin during labour and delivery?
Stimulates the ripening of the cervix and contractions of the uterus
Also plays a role in lactation during breastfeeding
What is oxytocin used for in labour?
Induce labour
Progress labour
Improve the fequency and strength of uterine contractions
Prevent or treat PPH
What is a brand name for oxytocin?
Syntocinon
What is atosiban? When is it used?
Oxytocin receptor antagonist which can be used as an alternative to nifedipine for tocolysis in premature labour (when nifedipine is contraindicated)
What is ergometrine?
Medication to stimulate smooth muscle contraction, both in uterus and blood vessels
Derived from ergot plants
Useful for delivery of the placenta and reduces post partum bleeding
When can ergometrine be used?
Only in the 3rd stage of labour (delivery of the placenta - not in 1st or 2nd) and postpartum to prevent and treat PPH
Whar are the side effects of ergometrine?
Due to action on smooth muscle and GI tract:
Hypertension
Diarrhoea
Vomiting
Angina
When should ergometrine be avoided?
Eclampsia (and with significant caution in those with hypertension)
What is syntometrine? When is it used?
Combination drug containing oxytocin (syntocinon) and ergometrine
Used for prevention/treament of PPH
How do prostaglandins work in labour?
Stimulating contraction of the uterine muscles
Ripening the cervix before delivery
What prostaglandin is used in inducting labour?
Dinoprostone which is prostaglandin E2
What form does dinoprostone come in?
Vaginal pessaries (Propess)
Vaginal tablets (Prostin tablets)
Vaginal gel (Prostin gel)
How do prostagandins act in general?
Vasodilators, lowering blood pressure