Labetalol Flashcards

1
Q

What is another name for Labetalol?

A

Trandate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What kind of drug is Labetalol?

A

Alpha and Beta adrenergic blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How does Labetalol work?

A

Alpha1 receptor blocker
Nonselective Beta receptor blocker
It lowers blood pressure in a hypertensive crisis. Blood pressure is reduced without reflex tachycardia, and total peripheral resistance is decreased, helping maintain cardiac output. Usually given IV in emergency care.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the onset of Labetalol?

A

within 5 minutes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the duration of Labetalol?

A

3-6 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are indications for Labetalol?

A
  • hypertensive emergencies
  • suspected MI and unstable angina
  • useful as adjunctive agent with fibrinolytic therapy
  • convert to NSR or to slow ventricular response in supraventricular tachydysrhythmias
  • reduce myocardial ischemia in AMI patients with elevated HR and BP or both
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are contraindications for Labetalol?

A
  • hemodynamically unstable patients
  • STEMI if there is signs of increased risk cardiogenic shock
  • 2nd or 3rd degree block, active asthma, reactive airway disease, severe bradycardia or SBP <100mmhg
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are some adverse reactions of Labetalol?

A
  • headache, dizziness, fatigue, flushing, diaphoresis, N/V
  • edema
  • vertigo
  • ventricular dysrhythmias
  • dyspnea
  • allergic reaction
  • dose-related orthostatic hypotension
  • bradycardia
  • tinnitus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are some drug interactions with Labetalol?

A
  • bronchodilator effects of beta-adrenergic agonists may be blunted by Labetalol
  • Nitro may augment hypotensive effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How is Labetalol supplied?

A

5mg/mL in 4-, 8-, 20-, and 40-mL vials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the IV dose of Labetalol?

A

10mg IV over 1-2 minutes

may repeat or double Labetalol every 10 minutes to a max dose of 150mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the dose for Labetalol infusion?

A

mix 200mg in 250mL of D5W

infuse at 2-8mg/min, titrate to supine BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are some special considerations for Labetalol?

A
  • pregnancy safety category C
  • observe for signs of CHF, bradycardia and bronchospasm
  • Labetalol should only be administered when the patient is supine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly