Lab work Flashcards
Risk factors for sepsis
Pre-term premature rupture of membranes (PPROM)
Premature onset of labour
Ruptured membranes over 18 hours
Define early vs Late onset of sepsis
Early - within 72 hours of life
Late - Post 72 hours
Gram + and Gram -
Gram + = Group B strep
Gram - = escherichia coli
Gent (levels at 5-7 days if needed) loading + Amp 12 h.
Viral organisms
HSV - T1 or T2 (can be in the genital tract without mum knowing). If mum caught during preg. the likelihood of severe infection is high.
Rubella
Cytomegalovirus (CMV)
What will a FBC show
FBC
WCC
Plalets
CRP in the infant
Dose not cross the placenta so results obtained reflect the infant’s level.
> protein produced by the liver cells during inflammation, trauma, or tissue necrosis
CRP is an “acute phase” test
CSF
- Glucose + protein concentration
- Meningitis
- Gram stain and culture
Renal function tests on a newborn
Blood, urea, nitrogen (BUN)
Creatine
Immature to total ratio
Most sensitive test for estimating the risk of infection that is present
When more than 20-25% of neutrophils in the blood are immature neutrophils suspicion should be that the infant is responding to an infection (as they are dying off and not cycling)
Low Platelet count - why and types
Thrombocytopenia
1 - decreased platelet production
2. increased platelet utilisation
THINGS THAT CAN DESTROY
- Infection e.g. HIV , CMV , Rubella
- Preg inducted HTN
- Materal immunosuppression
- Chromosomal
Platelet levels
less then 100,000 / ul > examine for signs of bleeding + re-examine
less then 50,000 / ul > Termed “severe”, risk of bleeding is increased. If they have no petechiae and nil signs of bleeding re-check.
less then 25, 000 / ul > transfusion and treat
