Lab Values Flashcards
Lab Values are used for
screening
diagnosis
monitoring
Factors affecting lab values
age, gender, race, pregnancy, food ingestion
Females and pediatric lab values are typically
less than normal
CBCs are typically ordered for
bleeding
infection
fluid status
anemia/weakness
CBC measures
RBC
Hgb
Hct
Platelet
WBC
MCV
MCH
MCHC
RDW
RBC
of red cells per mL/blood / 1mm3 of blood
- carry O2
- contains Hgb molecules
Hgb (Hemoglobin)
O2 carrying protein
Hct (Hemocrit)
packed volume of RBCs, % of total volume
MCV
Cell size (normocytic, macro and micro)
MCH
amount of hemoglobin per cell
MCHC
Hgb/Hct per 100 mL/RBCs
RDW
red cell distribution width
Platelet
of platelets per mL/blood
WBC
of white cells per mL/blood
RBC Normal values
3.89-5.40 M/uL
RBC indices
MCV
RDW
MCH
MCHC
not discussed
MCV: 80-95 fL
RDW: 11-14.5%
MCH: 27-31 pg
MCHC: 32-36 g/dL
High RBC > 5.4 M/uL
CHD
severe COPD
polycythemia vera (blood cancer)
severe dehydration
When RBC decreases more than 10% of the normal range what does the pt have?
anemia
Low RBC < 3.89
anemia
hemolytic anemia
hemorrhage
renal disease
normal pregnancy
bone marrow failure
rheumatoid arthritis, lymphoma, leukemia, Hodgkin disease, hemoglobinopathy, cirrhosis, dietary deficiency, bone marrow failure, prosthetic valves,
Hgb Normal Values
12-16 g/dL
- measurement of the total amount in blood
- connected to O2
High Hgb >16
erythrocytosis,
CHD
severe COPD,
polycythemia vera
severe dehydration
Low Hgb < 12
anemia
hemolytic anemia
hemorrhage, dietary deficiency, bone marrow failure
renal disease
normal pregnancy
prosthetic valves, rheumatoid arthritis, lymphoma, leukemia, Hodgkin disease, hemoglobinopathy, cirrhosis,
- low O2 to body tissues
How many hemoglobins are on every RBC?
4
Hct Normal Values
37-47 %
-indirect measurement of RBC number and volumes
-routine tests and anemia eval
Hct Critical Values**
<15%
>60%
High Hct >47%
erythrocytosis, congenital heart disease, severe COPD, polycythemia vera, severe dehydration
Low Hct <37%
anemia, hemoglobinopathy, cirrhosis, hemolytic anemia, hemorrhage, dietary deficiency, bone marrow failure, prosthetic valves, renal disease, normal pregnancy, rheumatoid arthritis, lymphoma, leukemia, Hodgkin disease
What are the three causes of anemia
= Impaired RBC production
= Blood loss
= RBC destruction
= Combination of all 3
What are 3 values important for diagnosing anemia?
Hct, Hgb, RBC
Anemia
Greater than 10% loss
Decrease in the number of RBCs (erythrocytes)
Platelet average count
150,000
- per mL of blood
- formed in bone marrow and to clot
High thrombocytosis >150,000
malignant disorders, polycythemia vera, post-splenectomy syndromes, rheumatoid arthritis, iron deficiency anemia
> 1 million of platelets
risk of clotting unnecessarily
> 600,000 of platelets
potential for problems
Where are thrombocytes formed?
bone marrow
What level of platelet count do you not give enoxaparin?
80,000
- pt education: fall risk, avoid cuts
Low (thrombocytopenia) < 150,000
hypersplenism, hemorrhage immune thrombocytopenia, leukemia, thrombotic thrombocytopenia, Graves disease, inherited disorders, DIC,
pernicious anemia, hemolytic anemia, cancer, chemotherapy, infection
< 50,000 of platelets
significant bleeding
WBC normal values
3.6-10.8 K/uL
-Measurement of total WBC count
-Part of routine testing on CBC
-White cell differential count if abnormal
~percentage of each type of leukocyte present in the specimen
High WBC >10.8
(leukocytosis): infection, inflammation, tissue necrosis, sepsis, Leukemic neoplasia, trauma, stress, dehydration, thyroid storm
Low WBC <3.6
(leukopenia): bone marrow failure, chemo radiation therapy, overwhelming infections, autoimmune disease
What lab value is used as an evaluation for suspected anemic pts?
hemoglobin
Leukocytosis
abnormally high number of leukocytes
WBC > 10,000 cells/mL3
Lymphocytosis
form of actual or relative leukocytosis due to increase in numbers of lymphocytes
Left shift
increase of immature neutrophils (bands/stabs) found in the blood
-normal differential values show where
BMP measures
Kidney function
Blood glucose
Acid/base balance
Electrolyte imbalance
BMP includes
Blood urea nitrogen
Creatinine
Glucose
Carbon dioxide content
Calcium
Chloride
Potassium
Sodium
CMP
BMP plus
Blood proteins
Liver function
CMP includes
Albumin
Total protein
Alkaline phosphatase (ALP)
Aspartate aminotransferase (AST)
Alanine aminotransferase (ALT)
Bilirubin
+ BMP
Glucose normal value
70-110 mg
Direct measurement of fasting blood glucose level
AKA blood sugar
-depend on when they last ate
- don’t always give insulin right away
High glucose >110
(hyperglycemia): Diabetes mellitus, acute stress response, Cushing syndrome, chronic renal failure, glucagonoma, acute pancreatitis, diuretic therapy, corticosteroid therapy, acromegaly
- recently ate a cheeseburger or ice cream
Low glucose <70
(hypoglycemia): insulinoma, hypothyroidism, hypopituitarism, Addison disease, extensive liver disease, insulin overdose, starvation
- have not eaten in a while
Glycosylated Hemoglobin A1c normal (nondiabetic)*
4-5.9%
monitor diabetes and the treatment of diabetes
average blood glucose level of the last 3 months
not dependent on last meal
Glycosylated Hemoglobin A1c
GOOD CONTROL*
<7%
Glycosylated Hemoglobin A1c
FAIR DIABETIC CONTROL*
8-9%
Glycosylated Hemoglobin A1c
POOR DIABETIC CONTROL*
> 9%
What electrolyte is important to cardiac function?
potassium
What electrolyte usually follows sodium in the body and utilizes passive transport?
chloride
What electrolyte plays a major role in acid/base balance and evaluating pH status and electrolytes?
Bicarbonate
What organ regulates bicarbonate?
kidneys
What value is used to monitor parathyroid function?
calcium
What value assists in the interpretation of parathyroid and calcium abnormalities?
phosphorus
What organ regulates electrolytes?
kidneys
What electrolyte is important in calcium metabolism and is closely tied to calcium levels?
Where is it regulated?
Magnesium
- Intracellularly and in bone
What is total protein a combination of?
pre-albumin
albumin
globulins
When is bilirubin produced?
hemoglobin breakdown
Sodium normal
135-145
Major cation in the extracellular space
Balance between dietary sodium intake and renal excretion (maintain homeostasis)
High sodium > 145
(hypernatremia): increased dietary intake, excessive sodium in IV fluids
Low sodium <135
(hyponatremia): deficient dietary intake, deficient sodium in IV fluids, increased free water in the body
Potassium normal
3.5-5.1
-important cardiac function
- major cation within the cell
High potassium >5.1
(hyperkalemia): excessive dietary or IV intake, acute or chronic renal failure, Addison disease, hypoaldosteronism, aldosterone inhibiting diuretics, crush injury to tissues, hemolysis, transfusion of hemolyzed blood, infection, acidosis, dehydration
Low potassium <3.5
(hypokalemia): deficient dietary or IV intake, burns, GI disorders, diuretics, hyperaldosteronism, Cushing syndrome, renal tubular acidosis, licorice ingestion, insulin administration, glucose administration, ascites, renal artery stenosis, cystic fibrosis, trauma, surgery, burns
Chloride normal
98-109
Major extracellular anion
Transport is **passive and usually follows sodium