Lab | Ingredient Considerations in Compounding

Question 1

Recommended source of ingredients for compounding

Answer 1

USP, NF, or FCC substance

Question 2

Alternative source of ingredients for compounding

Answer 2

Analytical reagent (AR) or certified American Chemical Society (ACS) grade

Question 3

Manufactured drug products as source of active ingredients must come from

Answer 3

containers with a batch control number and a future expiration date

Question 4

All ingredients in the manufactured drug product must be considered relative to

Answer 4

The intended use of the compounded preparation

Question 5

Ingredients in the manufactured drug product must be used for their __________, not the __________

Answer 5

intended use; off-label use

Question 6

Compounding databases used nowadays are

Answer 6

www.Lexicomp.com and www.compoundingtoday.com

Question 7

Reference materials for compounding: H-A-T-M-A-P-R-A-T-H-U

Answer 7

• Handbook of Extemporaneous Preparation
• Ansel’s Pharmaceutical Dosage Forms and Drug
  Delivery Systems
• The Art, Science, and Technology of Pharmaceutical Compounding
• Merck Index
• Applied Pharmaceutics in Contemporary Compounding
• Pharmaceutical Compounding and Dispensing
• Remington: The Science and Practice of Pharmacy
• A Practical Guide to Contemporary Pharmacy Practice
• Trissel’s Stability of Compounded Formulations
• Handbook of Injectable Drugs
• USP/NF

Question 8

Merck Index contains the physical/compounding characteristics of __________ and __________

Answer 8

active ingredients; excipients

Question 9

Merck Index is embedded in

Answer 9

Lexicomp

Question 10

Trissel’s Stability of Compounded Formulations is also a good reference for compounding __________ products

Answer 10

sterile

Question 11

Reference material that contains incompatibilities of sterile preparations

Answer 11

Trissel’s Stability of Compounded Formulations

Question 12

Reference material that is considered the most expensive source of ingredients and used as the reference standard

Answer 12

USP/NF

Question 13

During compounding, we are not required to
use __________. The only downside is that it is __________.

Answer 13

USP/NF; expensive

Question 14

Aside from USP/NF, AR claim, and ACS certified reagents, __________ can be used in the hospital or community hospital.

Answer 14

commercially available drug products

Question 15

As an alternative to USP/NF, __________ or __________ can be used.

Answer 15

analytical reagent claim; certified reagent of the American Chemical
Society

Question 16

Considerations when using commercially available drug product

Answer 16

• Batch number
• Future expiration date of the product
• Intended use, not the off-label use

Question 17

Special considerations with hydrates and solvates involves compounds with

Answer 17

molecules of water

Question 18

General rule in compounding with hydrates and solvates: The more molecules of __________ present in the molecule, the more of the chemical should be weighed to obtain the __________.

Answer 18

water; actual active drug

Question 19

Dexamethasone contains less than __________ of its weight in water.

Answer 19

0.5%

Question 20

__________ has one molecule of water of hydration and contains between 3.5 and 4.5% water; the __________ contains less than 0.4% water.

Answer 20

Dexamethasone acetate; anhydrous form

Question 21

__________ contains a sum of water and alcohol that may be up to 16.0%.

Answer 21

Dexamethasone sodium phosphate