Lab findings Flashcards
1
Q
Reed sternberg cells
A
NHL
2
Q
Auer rods
A
APML
3
Q
Blast cells
A
AML
4
Q
Starry sky
A
Burkitt Lymphoma
5
Q
HbH inclusions
A
Beta4 quartemers
HbH disease in Alpha Thal 3 gene deletion (NTDT)
6
Q
Spurr cell/Acanthocyte
A
Post spleenectomy
Liver dis
7
Q
Spurr cell/Acanthocyte RBC
A
Post spleenectomy
Liver dis
8
Q
Burr cell/Echinocyte RBC
A
Artifact
Ureaemia
Liver dis
9
Q
Schistocyte RBC
A
MAHA
valve damaged
10
Q
Bite cell RBC
A
G6PD
11
Q
Spherocyte RBC
A
AIHA
Hereditary spherocytosis
- AbN RBC mmb (skeleton) 2⁰ protein mutation
- Important proteins ↓ : Ankyrin, Band 3, Spectrin, Protein 4.2 (six60)
- AD inheritance / variable
- Detect by reduction in EMA fluorescence
- Spleenectomy may be needed if symptomatic anaemia
12
Q
Target Cell RBC
A
- Thalasseamia
- Haemaglobulinopathies
- Post spleenectomy
- Liver Dis
- Artifact
13
Q
Tear drop RBC
A
Myelofibrosis
underlying marrow problem/infiltrate
14
Q
RBC agglutinate
A
- Cold AIHA
- Paroxysmal cold heamoglobinaemia
- IgM assoc Lymphoma
- MM
15
Q
Rouleaux RBC
A
- MM
- Lymphoma
- Liver
- Chronic inflamm
16
Q
Smear cells
A
CLL
17
Q
Howell-Joly bodies
A
Speen - damaged/absent
Also in MDS, sickle cell, haemolytic anaemia, amyloidosis, megaloblastic
18
Q
B cell markers
A
B19-23
Surface Ig
Primarily CD19 and CD20
19
Q
T cell markers
A
CD 2-8
- CD3 - primary T cells
- CD4 - T h
- CD8 - T cyto (but also 30% of NK cells)
- CD45RA - naive
- CD45RO - memory
20
Q
Stem cell markers
A
CD34, CD45, HLA-Dr
21
Q
NK cells
A
- CD16?
- CD56
- CD57
