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laboratory animal science > lab animal past q > Flashcards

lab animal past q Flashcards

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Biology 101 flashcards
1
Q

This gland is not a specific pheromone producer gland

A

Rabbit’s face gland

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2
Q

specific pheromone producer gland

A

Gerbil’s umbilical gland
Dog’s cicumanal gland
Hamster’s hip gland

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3
Q

Which is not a method for genetic quality control of lab animals?

A

Back gross breeding

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4
Q

methods for genetic quality control of lab animals?

A

Skin transplantation
SSLP (micro-satellite)
Biomedical markers

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5
Q

Drawback of preference tests:

A

Animals choose in the base of short term conditions

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6
Q

Which measurement is used to express energy requirement of laboratory animals?

A

Metabolic body weight

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7
Q

Sentinels are

A

Animals used to evaluate a group’s health status

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8
Q

Which method wouldn’t you use to get 1mL of blood from a rat?

A

Cardiac puncture

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9
Q

You cannot buy this type of diet from a commercial supplier

A

Chemically defined diet

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10
Q

you can buy this type of diet from a commercial supplier

A

commercial pellet
liquid diet
gel

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11
Q

Not α2-agonist

A

Tolmetine

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12
Q

α2-agonist

A

xilazine
detomidine
romofidine

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13
Q

Not inherited disease of rat

A

Hypo-acidosis

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14
Q

inherited disease of rat:

A

deaf
diabetes
obesity

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15
Q

The basic method of rodent phenotyping is to look for

A

Chromosoma test

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16
Q

parts of refinement of animal experimentation

A

Genetic homogeneity
Health status
Proper defined diet

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17
Q

Which animals are covered by 63/2010 EEC directive

A

Vertebrates and Cephalipodes

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18
Q

GLP not concerned about conditions under which laboratory

A

The ones being built

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19
Q

Which species can die after oral penicillin treatment

A

Guinea pig

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20
Q

One of them is an important mechanism of nutrigenomics

A

Changing the signalling pathway

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21
Q

Acute toxicity test has an invasiveness category of __ pain

A

Severe

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22
Q

Maintenance energy requirements of laboratory animals

A

0.45MJ DE x W0.75

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23
Q

This disease is not a zoonosis

A

Ringtail

Sendai virus disease

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24
Q

this disease is zoonosis

A

Lymphatic choriomeningitis of mice
Salmonellosis
Listeriosis
Hantaan virus disease

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25
Q

The recommended nutrient allowances

A

Ensure the reproduction and longevity of the animals

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26
Q

Cannot be stage of mouse genital and urinary syndrome

A

Ulceration

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27
Q

Can be stage of mouse genital and urinary syndrome

A

Bacteraemia
Inflammation
Mating overload

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28
Q

Quarantine period not determined by

A

Number of animals

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29
Q

Quarantine period determined by

A

health status of the animals
species
purpose of use

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30
Q

Which species has a tied skin, so cannot grab it without causing pain to the animal?

A

Guinea pig

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31
Q

Not physical euthanasia method

A

Maceration

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32
Q

physical euthanasia method

A

T61
Cervical dislocation
Decapitation

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33
Q

Which species is not a member of Rodentia genus

A

Marmoset

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34
Q

Which species is a member of Rodentia genus

A

Golden hamster
Gerbil
Guinea pig

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35
Q

OECD do not deal with questions about

A

Validation of in vitro methods

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36
Q

Gerbil is a good model for

A

Epilepsy aorta

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37
Q

animal cannot be examined with ultrasound

A

Golden hamster

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38
Q

Not true for chronic mycoplasmosis of mice

A

Zoonosis

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39
Q

true for chronic mycoplasmosis of mice

A

Agent is Mycoplasma pulmonis
12-18 day old puppies are most disposed
Can appear with Sendai virus

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40
Q

The closest species to Syrian hamster in taxonomy is

A

Gerbil

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41
Q

Good species to use for auditory research

A

Chinchilla

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42
Q

Breeding technique which is not used to maintain an out-bred stock

A

Brother-sister mating

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43
Q

Breeding technique which is used to maintain an out-bred stock:

A

Random breeding
MAI
cross-breeding

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44
Q

A contaminated breeding colony (line) should be

A

Euthanized
Put under negative pressure cabin
Treated by antibiotics
Individually marked

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45
Q

In reproductive toxicology, not acceptable treatment

A

Used only for parents before mating
Between implantation and foetogenesis
Between foetogenesis and parturition From parent before mating till separation from dam

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46
Q

It can be used for intra-dermal injection

A

Mice ear

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47
Q

Pasteurella pneumotropica does not attack

A

Brain

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48
Q

Pasteurella pneumotropica does attack

A

Uterus
Prostate
Lung

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49
Q

Environmental enrichment should not be done

A

Just for human fun

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50
Q

Environmental enrichment should be

A

For the benefit of the animals
With the sense of animals
With some unpredictability

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51
Q

How would you restrain a gerbil

A

Hand around the chest

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52
Q

Who will decide on institute level if an animal experiment was necessary or not

A

Ethical committee (Animal Welfare Body)

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53
Q

This female embryo in a rat will achieve breeding maturity (M=Month

A

1 M

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54
Q

The basic method of rodent sexing is to look fo

A

Ano-genital distance

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55
Q

The recommended nutrient allowances

A

Ensure the optimum functioning of the animals

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56
Q

Maintenance energy requirements of laboratory animals and for extrapolation of dosage use

A

W 0.75

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57
Q

The main body of Laboratory Animal Science of the World

A

CALAS (the Canadian association for laboratory animal science)

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58
Q

The closest species to Syrian hamster in taxonomy is

A

Gerbil

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59
Q

What ‘Environmental Enrichment’ means in laboratory

A

To give bedding material or toys to experimental animal if possible

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60
Q

Feeding rancid feed and/or vitamin E deficient feed may cause

A

Dermatitis

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61
Q

Zebradanio is

A

Omnivore

62
Q

It is an alternative use of animals in experiments

A

Database search and meta-analysis

63
Q

Sub-cutaneous injury has a severity category of __ pain

A

Minor

64
Q

Which 3 words called the 3 R s by Russel and Burch

A

Reduction, Replacement, Refinement

65
Q

It is not true about euthanasia

A

Can be used to get large amount of blood out of an animal

66
Q

What does ‘knock out animal’ mean

A

Transgenic animal

67
Q

Which method would you use to get a drop of blood from mice?

A

Retro-orbital puncture

68
Q

Which name indicates an outbred stock?

A

.lr:NMRI

69
Q

You cannot use this method for euthanasia on rat

A

Ketamine

70
Q

You can use this method for euthanasia on rat

A

Decapitation
Cervical dislocation with weight limit
CO2 inhalation

71
Q

What is the best equipment to maintain a transgenic colony

A

Base colony in different countries

72
Q

Which species has only provoked (stimulated) ovulation

A

Ferret

73
Q

What does the expression ‘inbred strain’ mean

A

Brother-sister mating through at least 20 generations

74
Q

Which species is the best in atherosclerosis research

A

WHHL-rabbit

Notes – Gerbil

75
Q

You can find a ‘sacculus rotundus or ampulla ilei’ in the

A

Rabbit

76
Q

This gland is a specific pheromone producer gland

A

Hamster’s lateral gland

77
Q

Which species has a gallbladder

A

Golden hamster

78
Q

What does SPF mean

A

Specific Pathogen Free

79
Q

How would you restrain a rat for per-oral dosing

A

By grabbing the skin on back and neck

80
Q

Which sentence is not true about ‘Environmental Enrichment’

A

Device in case that animal can control

81
Q

true about ‘Environmental Enrichment’

A

All possibilities should be done to improve animal’s well-being what the experiment allows
Always should be evaluated on cross-benefit base
A nest material is an example for that

82
Q

Gnotobiotic (=Axenic) animals

A

Germ free

83
Q

What does rederivation mean?

A

Production of germ-free strain by embryo transfer

84
Q

In the practice, it is not possible to produce germ-free colony from this species

A

Duck

85
Q

Which would be the best feeding regime in an experiment

A

Ad libitum

86
Q

What is well-being

A

State of physiological and psychological harmony of the animal with its internal and external environment

87
Q

Which vein can be used for IV injection on ferret

A

Jugular vein

88
Q

How would you restrain a rabbit

A

By grabbing as much skin as possible on back

89
Q

You cannot use this method for euthanasia on new-born, nest-living animals

A

CO2 inhalation

90
Q

Which method would you use you get 10mL of blood from an adult rat?

A

Preparation of abdominal aorta

91
Q

Which mouse strain is sensitive to Pneumocystis carini

A

Swiss

92
Q

Which is not necessary before transport of rodent?

A

Fasting

93
Q

necessary before transport of rodent

A

Clinical examination
Ear printing
Acclimatisation

94
Q

When this phenomenon disappears, the narcosis ends with death

A

Cornea reflex

95
Q

It is not true about euthanasia

A

Should be cheap

96
Q

true about euthanasia

A

Should achieve rapid unconciseness and death
Should be safe for user
Should be simple to administer

97
Q

not true about the co-isogenic strains

A

It can only be maintained in a homozygous form

98
Q

true about the co-isogenic strains

A

The new gene is the product of natural maturation
The name contains the strain/sub-strain and the symbol of the mutant gene
The co-isogenic strain only differs by only one gene from the original one

99
Q

Dog is not a good model for

A

Cardiovascular atherosclerosis

100
Q

Dog is a good model for

A

Tumour-cancer research
Leptospirosis
Epilepsy

101
Q

Mini-pig has a live weight of

A

20-45 kg

102
Q

Experimental design cannot be

A

Cross-breeding

103
Q

Experimental design can be

A

Cross-over design
Latin square design
Factorial design

104
Q

The basal circadian rhythm is

A

Dependent from the gen expression of a protein

105
Q

Melatonin is produced by

A

Pineal gland

106
Q

This species mostly used in viral respiratory research

A

Ferrets

107
Q

A chronic stress can cause this type of behaviour

A

Apathy / Aggression

108
Q

Well-being cannot be measured by (more than one correct answer)

A

Clinical assessment
Physiological parameters
Grimace score
Reproductive state

109
Q

Which environment is good for animals?

A

Classical music

110
Q

Which tissue is the least sensitive to suffering?

A

Brain tissue

111
Q

The naked mole rat has an extra=ordinary long life-span because of

A

Special hyaluronan which prevent cancer

112
Q

The co-efficient on inbreeding (F

A

Means the fraction of the genes that get fixed in a homozygous state

113
Q

It is inherited disease of some mouse strains

A

Deafness

114
Q

Which is a member of Pox viridae

A

Ectomelia virus

115
Q

Ringtail is caused by

A

Too low relative humidity

116
Q

Not part of refinement of animal experimentation

A

Hair colour

Alternative use of animals

117
Q

part of refinement of animal experimentation

A

Health status
Analgesia
Environmental enrichment

118
Q

The hearing range of rodents

A

0.5 / 1 - 100 / 120 kHz

119
Q

Which species has 1 pair teats

A

Guinea pig

120
Q

Which species has a ‘peg’ (double incisors) teeth

A

Rabbit

121
Q

The two important words for animals concerning the pain feeling (Weiss-trail)

A

Predictability and controllability

122
Q

Mouse pox is

A

Caused by Ectomelia

123
Q

It is not a physical euthanasia method

A

Cooling in refrigerator

124
Q

a physical euthanasia method

A

T61
Cervical dislocation
Decapacitation
CO2 inhalation

125
Q

The African clawed for (Xenopus)

A

Shows mating behaviour after Hcg injection

126
Q

The axolotl is not

A

Reaches adulthood after a complete metamorphosis

127
Q

The axolotl is

A

Capable of regenerating lost limbs completely
Carnivorous
Has a long lifespan (8-10 years)

128
Q

Laboratory animals – except the guinea pig – usually adjust their feed intake to satisfy their

A

Energy requirement

129
Q

Which species can die after oral antibiotic treatment

A

Guinea pig and rabbit

130
Q

The role of PPAR is to

A

Burn fats

131
Q

One of the following has no anti-cancer effect

A

Iron

132
Q

the following has anti-cancer effect:

A

Resveratrol
CLA
Green tea

133
Q

an important mechanism of epigenomics

A

Methylation of DNA

134
Q

Zebrafish has a life-span of __year:

A

6-8

3-5 years according to internet

135
Q

One of them has no role in epigenomics

A

Change of base in DNA

136
Q

The role of __ is a fine regulation of the protein synthesis in the cell

A

miRNA / siRNA

137
Q

In some cases the epigenetic changes may be inherited

A

If the effect(s) acts during the germ-cell proliferation (‘time window’)

138
Q

You can find neoteny at

A

Axolotl

139
Q

Pheromones are detected by

A

VNO

140
Q

true about the ferret

A

We can prevent the constant estrus by using GnRH agonist implants

141
Q

The cephalopods

A

Are under the protection of the 2010/63/EU Directive since 2013

142
Q

One of the statements is true

A

Animals in an outbred stock are anisogenic

143
Q

A chromorhnydachyrrhea

A

Vitamin A deficiency

144
Q

It can go through the uteral wall

A

Mouse mammary tumour

LCM

145
Q

Carbohydrate ingestion

A

Stimulate the fatty acid synthase gene expression

146
Q

May increase the mitochondria number

A

Resveratrol

147
Q

The most used model for drug metabolism study for humans

A

Macaco

148
Q

Describe the naked mole rat as an animal model.

A
  • Have a gene which conserves collagen.
  • Do not age.
  • Do not get tumours.
  • Life-span of 20-30 years.
  • Complex social system and hierarchy.
  • Best model for aging and cancer studies
149
Q

Describe the evaluation of the Glires pain categories

A
  • Based on appearance, behaviour, pulse, appetite/drinking, cardiovascular, digestive, and nervous systems.
  • 0-4 = Normal
  • 5-9 = Needs analgesia
  • 10-14 = Moderate pain, possible need to terminate trial
  • 15-20 = Not physiological, stop experiment!
150
Q

Explain the pain scoring system for Glires

A
  • 0 points = None
  • 1 point = Mild
  • 2 points = Moderate
  • 3 points = Severe
151
Q

Explain the epigenetics’ mechanism of action

A
  • Modifications e.g. Methylation, histone acetylation, which protect DNA and modify which genes are expressed or silenced.
  • Do not change the genome itself
  • May be inherited
  • Influenced by outside stimuli e.g. nutritional status

laboratory animal science (1 decks)

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