Lab 5 Cartilage Flashcards
The most prevalent cartilage in vertebrates
Hyaline cartilage
Where in synovial joints is hyaline cartilage found
At the articular surface (knee and shoulder)
This tissue is resilient and can withstand compressive force
Hyaline cartilage
Trachea is an example of what cartilage
Hyaline
Is hyaline cartilage ECM vascular
No
What kind of fibers are embedded in the ground substance of the hyaline ECM
Type 2 collagen fibers
Why does hyaline cartilage have a basophilic stain
Sulfate groups on proteoglycans attract basic dyes
How many layers is the perichondrium
2 layers
What is the outer layer of perichondrium made of
DICT (type 1 collagen)
What cells are in the outer layer of perichondrium
Fibroblasts
Describe inner layer of perichondrium
Inner layer is chondrogenic and has 2-3 layers of flat, fibroblast-like chondrogenic cells
These cells have the capacity to become Chondroblasts
Chondrogenic cells
Young cartilage cells that are more round than perichondrial cells and are in the inner perichondrium layer
Chondroblasts
What secretes the ECM and what does it eventually become
Chondroblasts secrete the ECM and become chondrocytes
During tissue prep, chondrocytes retract from …… leaving gaping holes
Lacunae
Daughter cells of mitotic division that are clustered chondrocytes
Isogenous groups
ECM immediately enveloping chondrocytes
Territorial matrix
Wide space of ECM
Interterritorial space
The structure of elastic cartilage is similar to hyaline cartilage except that the ECM contains
The ECM contains elastic fibers
What synthesizes elastic fibers
Chondrocytes
Is elastic cartilage vascular in adults
No
True or false: Fibrous cartilage is vascular
False, it is avascular
T/F: fibrocartilage has a perichondrium
False
Fibrocartilage is a hybrid tissue, meaning:
It has dense connective tissue and hyaline cartilage
What type of collagen does the fibrocartilage ECM have
Type 1 and 2 collagen
Does fibrocartilage have a lot of PGs
Fibrocartilage has a low concentration of proteoglycans
Fibrocartilage has good tensile strength T/F
True
Fibrocartilage lies between
Hyaline cartilage and dense connective tissue
In vertebrates, most skeletal elements from the neck down form by
Endochondral Ossification
The resting zone is …
Unaffected by EO and randomly scattered with chondrocytes
Zone of proliferation
Stacking chondrocytes
Zone of hypertrophy
Swelling chondrocytes
Zone of degradation
One terminal hypertrophic layer facing trabecular bone and marrow
Zone of ossification
Trabecular bony spicules with hypertrophic cartilage cores
Osteoclasts are derived from
Monocytes lineage and are multinucleate
Howship’s lacunae
Resorption pits contain osteoclasts present on trabecular bone
Bone-resorbing cells in zone of ossification
Osteoclasts
